Chronic stress, social support, and Alzheimer's blood-based biomarkers in the HABS-HD study

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-03-05 DOI:10.1002/alz.70043

Jillian K. Lee, Leigh Johnson, James R. Hall, James R. Bateman, Lisa L. Barnes, Sid O'Bryant, Michelle M. Mielke

{"title":"Chronic stress, social support, and Alzheimer's blood-based biomarkers in the HABS-HD study","authors":"Jillian K. Lee, Leigh Johnson, James R. Hall, James R. Bateman, Lisa L. Barnes, Sid O'Bryant, Michelle M. Mielke","doi":"10.1002/alz.70043","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>High levels of chronic stress and low social support have been associated with worse cognition among older adults, but the underlying mechanisms remain unclear.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We included 2117 older adults (mean age 65.5 years) enrolled in the Health and Aging Brain Study – Health Disparities (HABS-HD). Linear regression models evaluated the associations between social support or chronic stress and Alzheimer's-related blood-based biomarkers (BBMs), including amyloid beta (Aβ) 42/40 ratio, neurofilament light chain (NfL), phosphorylated tau (p-tau)181, and total tau (t-tau). Interactions between chronic stress or social support and gender or race/ethnicity in relation to BBMs were assessed.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Higher chronic stress was associated with higher levels of t-tau. Higher social support was associated with lower levels of NfL. Neither gender nor race/ethnicity modified the associations between chronic stress or social support and BBM levels.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Chronic stress and social support are associated with BBMs of neurodegeneration.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Higher chronic stress was associated with higher levels of plasma total tau.</li>\n \n <li>Higher social support was associated with lower levels of plasma neurofilament light chain.</li>\n \n <li>Neither gender nor race/ethnicity modified the associations between chronic stress or social support and levels of blood-based biomarkers.</li>\n \n <li>Chronic stress and social support affect pathways related to neurodegeneration.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 3","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70043","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70043","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

High levels of chronic stress and low social support have been associated with worse cognition among older adults, but the underlying mechanisms remain unclear.

METHODS

We included 2117 older adults (mean age 65.5 years) enrolled in the Health and Aging Brain Study – Health Disparities (HABS-HD). Linear regression models evaluated the associations between social support or chronic stress and Alzheimer's-related blood-based biomarkers (BBMs), including amyloid beta (Aβ) 42/40 ratio, neurofilament light chain (NfL), phosphorylated tau (p-tau)181, and total tau (t-tau). Interactions between chronic stress or social support and gender or race/ethnicity in relation to BBMs were assessed.

RESULTS

Higher chronic stress was associated with higher levels of t-tau. Higher social support was associated with lower levels of NfL. Neither gender nor race/ethnicity modified the associations between chronic stress or social support and BBM levels.

DISCUSSION

Chronic stress and social support are associated with BBMs of neurodegeneration.

Highlights

Higher chronic stress was associated with higher levels of plasma total tau.
Higher social support was associated with lower levels of plasma neurofilament light chain.
Neither gender nor race/ethnicity modified the associations between chronic stress or social support and levels of blood-based biomarkers.
Chronic stress and social support affect pathways related to neurodegeneration.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.