Scam susceptibility is associated with a markedly accelerated onset of Alzheimer's disease dementia

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-03-05 DOI:10.1002/alz.14544

Patricia A. Boyle, Tianhao Wang, Gary Mottola, Chris Stewart, Robert S. Wilson, David A. Bennett, Lei Yu

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Abstract

INTRODUCTION

The association of scam susceptibility with the timing of Alzheimer's disease (AD) dementia onset is unknown.

METHODS

One thousand ninety-two older adults without dementia underwent assessments of scam susceptibility and annual clinical evaluations to document incident AD dementia. Accelerated failure time models examined the relation of scam susceptibility with dementia onset.

RESULTS

During a mean of 5 years of follow-up (standard deviation = 3.1), 188 individuals (17%) were diagnosed with incident AD dementia. A higher level of scam susceptibility was associated with a considerably earlier dementia onset ( $β$ = −0.039; 95% confidence interval: −0.061, −0.017); those with a high level of susceptibility developed AD dementia at a mean age of 90.9 years compared to 98.2 for those with a low level. Results persisted after controlling for global cognition, sex, and education.

DISCUSSION

Scam susceptibility is associated with a markedly earlier onset of AD dementia. Assessment of susceptibility may facilitate early identification of individuals at risk of developing dementia.

Highlights

We examined whether scam susceptibility among older adults is associated with an accelerated onset of Alzheimer's disease dementia.
Participants came from a large ongoing cohort study of aging.
Scam susceptibility was assessed using a validated measure.
Scam susceptibility was associated with a marked acceleration in dementia onset.
Assessment of susceptibility may facilitate early identification of dementia.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.