Margaret Kabakova, Jennifer Wang, Julia Stolyar, Evan Austin, Jared Jagdeo
{"title":"Visible Blue Light Does Not Induce DNA Damage in Human Dermal Fibroblasts","authors":"Margaret Kabakova, Jennifer Wang, Julia Stolyar, Evan Austin, Jared Jagdeo","doi":"10.1002/jbio.202400510","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Photobiomodulation (PBM) is a noninvasive treatment modality that utilizes light to influence cellular activity. PBM has applications in various dermatological conditions. As blue light (BL, 400–500 nm) therapy gains popularity, concerns about its potential to induce DNA damage remain. This study investigates the effects of fluorescent BL (417 ± 5 nm) on human dermal fibroblast DNA, specifically examining the formation of cyclobutane pyrimidine dimers (CPD) and 6-4 photoproducts (6-4PPs) at fluences of 10, 30, and 45 J/cm<sup>2</sup>. Our results demonstrate that BL exposure does not induce detectable DNA damage, in contrast to the well-documented effects of ultraviolet light, which is known to cause such damage. These findings support the safety of fluorescent BL therapy and align with prior research on LED-red and LED-near-infrared wavelengths. Continued clinical investigation of the effects of BL on skin will add to the understanding of the safety profile.</p>\n </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 5","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biophotonics","FirstCategoryId":"101","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202400510","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Photobiomodulation (PBM) is a noninvasive treatment modality that utilizes light to influence cellular activity. PBM has applications in various dermatological conditions. As blue light (BL, 400–500 nm) therapy gains popularity, concerns about its potential to induce DNA damage remain. This study investigates the effects of fluorescent BL (417 ± 5 nm) on human dermal fibroblast DNA, specifically examining the formation of cyclobutane pyrimidine dimers (CPD) and 6-4 photoproducts (6-4PPs) at fluences of 10, 30, and 45 J/cm2. Our results demonstrate that BL exposure does not induce detectable DNA damage, in contrast to the well-documented effects of ultraviolet light, which is known to cause such damage. These findings support the safety of fluorescent BL therapy and align with prior research on LED-red and LED-near-infrared wavelengths. Continued clinical investigation of the effects of BL on skin will add to the understanding of the safety profile.
期刊介绍：
The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
