Margaret Kabakova, Jennifer Wang, Julia Stolyar, Evan Austin, Jared Jagdeo
{"title":"Visible Blue Light Does Not Induce DNA Damage in Human Dermal Fibroblasts.","authors":"Margaret Kabakova, Jennifer Wang, Julia Stolyar, Evan Austin, Jared Jagdeo","doi":"10.1002/jbio.202400510","DOIUrl":null,"url":null,"abstract":"<p><p>Photobiomodulation (PBM) is a noninvasive treatment modality that utilizes light to influence cellular activity. PBM has applications in various dermatological conditions. As blue light (BL, 400-500 nm) therapy gains popularity, concerns about its potential to induce DNA damage remain. This study investigates the effects of fluorescent BL (417 ± 5 nm) on human dermal fibroblast DNA, specifically examining the formation of cyclobutane pyrimidine dimers (CPD) and 6-4 photoproducts (6-4PPs) at fluences of 10, 30, and 45 J/cm<sup>2</sup>. Our results demonstrate that BL exposure does not induce detectable DNA damage, in contrast to the well-documented effects of ultraviolet light, which is known to cause such damage. These findings support the safety of fluorescent BL therapy and align with prior research on LED-red and LED-near-infrared wavelengths. Continued clinical investigation of the effects of BL on skin will add to the understanding of the safety profile.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400510"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biophotonics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/jbio.202400510","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Photobiomodulation (PBM) is a noninvasive treatment modality that utilizes light to influence cellular activity. PBM has applications in various dermatological conditions. As blue light (BL, 400-500 nm) therapy gains popularity, concerns about its potential to induce DNA damage remain. This study investigates the effects of fluorescent BL (417 ± 5 nm) on human dermal fibroblast DNA, specifically examining the formation of cyclobutane pyrimidine dimers (CPD) and 6-4 photoproducts (6-4PPs) at fluences of 10, 30, and 45 J/cm2. Our results demonstrate that BL exposure does not induce detectable DNA damage, in contrast to the well-documented effects of ultraviolet light, which is known to cause such damage. These findings support the safety of fluorescent BL therapy and align with prior research on LED-red and LED-near-infrared wavelengths. Continued clinical investigation of the effects of BL on skin will add to the understanding of the safety profile.