Effect of Sequential Repetitive Transcranial Magnetic Stimulation With Bilateral Arm Training on the Brain Effective Connectivity in Chronic Stroke

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2025-03-04 DOI:10.1002/jbio.202400508

Wenhao Li, Ping Cao, Ran Wei, Duo Wai-Chi Wong

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Abstract

This study investigated the effects of combining repetitive transcranial magnetic stimulation (rTMS) with bilateral arm training (BAT) on effective brain connectivity in chronic stroke patients using functional near-infrared spectroscopy. Fifteen post-stroke patients and fifteen healthy individuals were enrolled. Coupling function analysis was performed to evaluate the effective connectivity inflow, outflow, and the dominant information flow (DIF) during standalone BAT and combined rTMS-BAT therapy. Significant task-related alterations were observed in the ipsilesional supplementary motor area and occipital lobe (OL) of stroke patients undergoing rTMS-BAT. During BAT, stroke patients exhibited more pronounced DIF from the OL to motor areas compared to healthy controls. Furthermore, in the rTMS-BAT condition, patients demonstrated enhanced DIF from the ipsilesional OL and contralesional prefrontal cortex to ipsilesional motor areas. These findings suggested a potential synergistic effect on cortical reorganization through the sequential combination of task-related training and TMS in chronic stroke patients, offering insights into rehabilitation strategies.

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连续重复经颅磁刺激联合双侧手臂训练对慢性脑卒中患者脑有效连通性的影响。

本研究利用功能近红外光谱技术研究重复性经颅磁刺激（rTMS）联合双侧手臂训练（BAT）对慢性脑卒中患者有效脑连通性的影响。15名中风后患者和15名健康人被纳入研究。通过耦合函数分析评估单独BAT和联合rTMS-BAT治疗期间的有效连通性流入、流出和优势信息流（DIF）。在接受rTMS-BAT治疗的脑卒中患者的同侧辅助运动区和枕叶（OL）中观察到显著的任务相关改变。在BAT期间，与健康对照组相比，卒中患者表现出更明显的从OL到运动区域的DIF。此外，在rTMS-BAT条件下，患者表现出从同侧OL和对侧前额叶皮层到同侧运动区的DIF增强。这些发现表明，在慢性脑卒中患者中，任务相关训练和经颅磁刺激的顺序结合可能对皮质重组产生潜在的协同效应，为康复策略提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.