Health inequalities in hepatocellular carcinoma surveillance, diagnosis, treatment, and survival in the United Kingdom: a scoping review.

Christopher Mysko, Stephanie Landi, Huw Purssell, A Joy Allen, Martin Prince, Gary Lindsay, Steven Rodrigues, Jenny Irvine, Oliver Street, Deepankar Gahloth, Sara MacLennan, Karen Piper Hanley, Neil Hanley, Varinder Singh Athwal
{"title":"Health inequalities in hepatocellular carcinoma surveillance, diagnosis, treatment, and survival in the United Kingdom: a scoping review.","authors":"Christopher Mysko, Stephanie Landi, Huw Purssell, A Joy Allen, Martin Prince, Gary Lindsay, Steven Rodrigues, Jenny Irvine, Oliver Street, Deepankar Gahloth, Sara MacLennan, Karen Piper Hanley, Neil Hanley, Varinder Singh Athwal","doi":"10.1038/s44276-025-00126-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) remains a deadly cancer in the UK despite advancements in curative therapies. Societal conditions and health inequalities influence the development of chronic liver disease and outcomes from complications including HCC. Scoping this emergent evidence-base is required to inform research and solutions for the NHS.</p><p><strong>Methods: </strong>A PRISMA scoping review was performed up to September 2023. Articles exploring health inequalities in HCC involving the UK population were included.</p><p><strong>Results: </strong>This review has characterised axes of health inequality and their impact across the HCC care continuum in the UK. Studies predominantly employed a cohort design or population-based analyses, with meta-analyses of surveillance utilisation including only a single UK study. These methodologies provided an appropriate lens to understand longitudinal trends and identify disadvantaged groups. However, important evidence gaps remain, including exploration of patient perspectives, intersectional analyses, and statistical measures of socioeconomic inequity in HCC.</p><p><strong>Conclusions: </strong>HCC is a rapidly growing cause of cancer mortality and disproportionally affects underserved groups, presenting a major public health concern. Further research is required to innovate and evaluate surveillance and management pathways to reduce systemic inequities. Direction is needed at the national level to improve prevention, early diagnosis and access to curative treatment.</p>","PeriodicalId":519964,"journal":{"name":"BJC reports","volume":"3 1","pages":"13"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876667/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BJC reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44276-025-00126-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Hepatocellular carcinoma (HCC) remains a deadly cancer in the UK despite advancements in curative therapies. Societal conditions and health inequalities influence the development of chronic liver disease and outcomes from complications including HCC. Scoping this emergent evidence-base is required to inform research and solutions for the NHS.

Methods: A PRISMA scoping review was performed up to September 2023. Articles exploring health inequalities in HCC involving the UK population were included.

Results: This review has characterised axes of health inequality and their impact across the HCC care continuum in the UK. Studies predominantly employed a cohort design or population-based analyses, with meta-analyses of surveillance utilisation including only a single UK study. These methodologies provided an appropriate lens to understand longitudinal trends and identify disadvantaged groups. However, important evidence gaps remain, including exploration of patient perspectives, intersectional analyses, and statistical measures of socioeconomic inequity in HCC.

Conclusions: HCC is a rapidly growing cause of cancer mortality and disproportionally affects underserved groups, presenting a major public health concern. Further research is required to innovate and evaluate surveillance and management pathways to reduce systemic inequities. Direction is needed at the national level to improve prevention, early diagnosis and access to curative treatment.

英国肝细胞癌监测、诊断、治疗和生存中的健康不平等:一项范围综述
背景:在英国,肝细胞癌(HCC)仍然是一种致命的癌症,尽管治疗方法有所进步。社会条件和健康不平等影响慢性肝病的发展和包括肝细胞癌在内的并发症的结果。需要确定这一紧急证据基础的范围,以便为NHS的研究和解决方案提供信息。方法:到2023年9月进行PRISMA范围审查。研究英国人群HCC健康不平等的文章被纳入。结果:本综述描述了健康不平等轴线及其在英国HCC治疗连续体中的影响。研究主要采用队列设计或基于人群的分析,监测利用的荟萃分析仅包括一项英国研究。这些方法为了解纵向趋势和确定弱势群体提供了适当的视角。然而,重要的证据差距仍然存在,包括对HCC患者观点的探索,交叉分析和社会经济不平等的统计测量。结论:HCC是一种快速增长的癌症死亡原因,不成比例地影响到服务不足的人群,引起了重大的公共卫生问题。需要进一步研究创新和评估监督和管理途径,以减少系统性不公平。需要在国家一级指导改进预防、早期诊断和获得治愈性治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信