Update on the Role of Cellular Redox System in Health and Illness.

Manvi Karayat, Kalpana Rahate, Shristi Singh
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Abstract

An imbalance between Reactive Oxygen Species (ROS) and antioxidants in the circulatory system leads to oxidative stress, which has been linked to several pathological conditions, including cancer, aging, and neurological and cardiovascular diseases. Antioxidants play a crucial role in re-ducing oxidative damage by neutralizing harmful free radicals and preventing cellular injury. The processes generating cellular oxidative stress and the curative effects of antioxidants, the origins and effects of reactive oxygen species (ROS), the role that oxidative stress plays in the pathogenesis of disease, and the several kinds of antioxidants-including enzymatic and non-enzymatic antioxidants are thoroughly explored in this review. We also emphasized the medicinal uses of antioxidants, both natural and synthetic, in the prevention and treatment of disorders associated with oxidative stress. Furthermore, we discussed the challenges and potential paths ahead for antioxidant research, such as developing new antioxidant molecules with higher efficacy and improving antioxidant delivery sys-tems. This study provides information regarding the complicated dynamics of oxidative stress and the potential benefits of antioxidants for preserving cellular homeostasis and advancing human health.

细胞氧化还原系统在健康和疾病中的作用研究进展。
循环系统中活性氧(ROS)和抗氧化剂之间的不平衡导致氧化应激,这与多种病理状况有关,包括癌症、衰老、神经系统和心血管疾病。抗氧化剂通过中和有害自由基和防止细胞损伤,在减少氧化损伤方面起着至关重要的作用。本文就细胞氧化应激的产生过程、抗氧化剂的治疗作用、活性氧(ROS)的来源和作用、氧化应激在疾病发病中的作用以及几种抗氧化剂(包括酶促抗氧化剂和非酶促抗氧化剂)进行了深入的探讨。我们还强调了天然和合成抗氧化剂在预防和治疗与氧化应激有关的疾病方面的药用价值。此外,我们还讨论了抗氧化剂研究面临的挑战和未来的潜在途径,如开发新的抗氧化剂分子和提高抗氧化剂的传递系统。本研究提供了关于氧化应激的复杂动力学和抗氧化剂在保持细胞稳态和促进人体健康方面的潜在益处的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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