Sex-specific effects of dietary salt intake on circulating Alzheimer's disease-related biomarkers in aged rats.

Abstract

This study collected plasma samples from aged male and female Sprague Dawley rats (22-24 months old) with varying long-term dietary salt intake (low, 0.1% NaCl; normal, 0.4% NaCl; or clinically relevant high salt, 1% NaCl; for twelve weeks). Dementia-related biomarkers in the plasma, including amyloid-β peptide 1-42, tau protein, and glial fibrillary acidic protein, were measured using enzyme-linked immunosorbent assay kits. The primary outcome revealed sex differences in the impact of dietary salt on these biomarkers.