The effect of probiotics on select cognitive domains in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis.

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2024-10-18 eCollection Date: 2024-01-01 DOI:10.1177/25424823241289039
Shashank Tripathi, Meenakshi Kaushik, Rekha Dwivedi, Prabhakar Tiwari, Manjari Tripathi, Rima Dada
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引用次数: 0

Abstract

Background: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are progressive neurodegenerative disorders, and probiotics may offer therapeutic benefits by modulating gut microbiota and reducing inflammation.

Objective: This study systematically evaluated the impact of probiotics on cognitive function in MCI and AD through a meta-analysis of randomized controlled trials (RCTs).

Methods: A systematic review and meta-analysis were performed following PRISMA 2020 guidelines. PubMed, Embase, EBSCO, and Cochrane databases were searched for RCTs (January 2000-January 2024) on probiotic interventions lasting 8-24 weeks. Cognitive outcomes included Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), language, naming, visual-spatial, memory, and attention. Data were analyzed using R with a random-effects model to calculate pooled standardized mean differences (SMDs) with 95% confidence intervals (CIs). Risk of bias was rigorously assessed.

Results: Out of 2000 articles, 500 full texts were screened, and 10 studies were included. The meta-analysis showed varied effect sizes: MMSE (SMD: 0.28, 95%CI -0.35-0.91, p = 0.38), MoCA (SMD: 0.51, 95%CI -0.49-1.52, p = 0.33), language (SMD: -0.12, 95% CI -0.54-0.29, p = 0.56), naming (SMD: 0.02, 95%CI -0.69-0.74, p = 0.95), visual-spatial (SMD: 0.38, 95%CI -0.13-0.88, p = 0.14), memory (SMD: 0.20, 95%CI -0.15-0.55, p = 0.26), and attention (SMD: -0.07, 95%CI -0.44-0.30, p = 0.71). Positive SMDs suggest cognitive improvement, while non-significant negative SMDs indicate trends toward decline, inclined by probiotic strains, duration, and participant characteristics.

Conclusions: Probiotics did not significantly improve cognitive function in MCI and AD patients, with variability in effects across cognitive domains, suggesting the need for tailored interventions and future studies.

益生菌对轻度认知障碍和阿尔茨海默病患者选择认知领域的影响:一项系统综述和荟萃分析。
背景:轻度认知障碍(MCI)和阿尔茨海默病(AD)是进行性神经退行性疾病,益生菌可能通过调节肠道微生物群和减少炎症提供治疗益处。目的:本研究通过随机对照试验(RCTs)的荟萃分析,系统评估益生菌对MCI和AD患者认知功能的影响。方法:按照PRISMA 2020指南进行系统评价和荟萃分析。检索PubMed、Embase、EBSCO和Cochrane数据库,检索2000年1月至2024年1月期间有关益生菌干预8-24周的随机对照试验。认知结果包括简易精神状态检查(MMSE)、蒙特利尔认知评估(MoCA)、语言、命名、视觉空间、记忆和注意力。采用随机效应模型计算95%置信区间(ci)的合并标准化平均差(SMDs),采用R法对数据进行分析。对偏倚风险进行了严格评估。结果:在2000篇文章中,筛选了500篇全文,纳入了10项研究。meta分析显示不同的效应大小:MMSE (SMD: 0.28, 95%CI -0.35-0.91, p = 0.38)、MoCA (SMD: 0.51, 95%CI -0.49-1.52, p = 0.33)、语言(SMD: -0.12, 95%CI -0.54-0.29, p = 0.56)、命名(SMD: 0.02, 95%CI -0.69-0.74, p = 0.95)、视觉空间(SMD: 0.38, 95%CI -0.13-0.88, p = 0.14)、记忆(SMD: 0.20, 95%CI -0.15-0.55, p = 0.26)、注意力(SMD: -0.07, 95%CI -0.44-0.30, p = 0.71)。积极的smd表明认知改善,而不显著的消极smd表明有下降的趋势,这与益生菌菌株、持续时间和参与者特征有关。结论:益生菌并没有显著改善MCI和AD患者的认知功能,在不同的认知领域有不同的效果,这表明需要量身定制的干预措施和未来的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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