Exploring causal relationship of traumatic brain injury and comorbidities: A Mendelian randomization study.

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI:10.1177/25424823241304393
Xiaohang Zhang, Wenze Wu, Yaqing Mao, Jiaxin Cheng, Zixuan Zhou, Yaqi Tang, Qiulong Zhao, Hui Yan
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引用次数: 0

Abstract

Background: Previous observational studies demonstrated a link existed between traumatic brain injury (TBI) and cerebral disease and multisystem complications, such as dementia, pneumonia, and gastrointestinal disease, but they could be confused by confounding and reverse causality.

Objective: We aimed to figure out the causal correlation between TBI and the following complications.

Methods: Database concerning TBI and complications from genome-wide association study (GWAS) and two-sample Mendelian randomization (MR) analysis was employed to examine whether TBI was causally associated with the risk of some complications. All the analysis was carried out through R, version 4.3.3.

Results: MR analyses indicated that any dementia has a promotional effect on TBI (OR = 1.067, 95% CI, 1.011-1.123, p = 0.017). However, there was no causal genetically association between TBI and Alzheimer's disease (AD), Parkinson's disease (PD), pneumonia, or gastrointestinal disease.

Conclusions: Contrary to observational studies, our results uncovered little causal association between TBI and PD, AD, depression, pneumonia, and gastrointestinal diseases. Interestingly, we found any dementia might be the risk of TBI, which was a new discovery.

探索创伤性脑损伤与合并症的因果关系:一项孟德尔随机化研究。
背景:先前的观察性研究表明,创伤性脑损伤(TBI)与脑疾病和多系统并发症(如痴呆、肺炎和胃肠道疾病)之间存在联系,但它们可能被混淆和反向因果关系所混淆。目的:探讨创伤性脑损伤与以下并发症的因果关系。方法:采用全基因组关联研究(GWAS)和双样本孟德尔随机化(MR)分析的TBI和并发症数据库,研究TBI与某些并发症的风险是否存在因果关系。所有的分析都是通过4.3.3版本的R进行的。结果:MR分析表明,任何痴呆对TBI都有促进作用(OR = 1.067, 95% CI, 1.011-1.123, p = 0.017)。然而,TBI与阿尔茨海默病(AD)、帕金森病(PD)、肺炎或胃肠道疾病之间没有因果遗传关联。结论:与观察性研究相反,我们的研究结果显示TBI与PD、AD、抑郁症、肺炎和胃肠道疾病之间几乎没有因果关系。有趣的是,我们发现任何痴呆都可能有患脑外伤的风险,这是一个新发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.80
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