Differential DNA methylation profiles of Alzheimer's disease-related genomic pathways in the blood of cognitively-intact individuals with and without high impact chronic pain.

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2024-11-24 eCollection Date: 2024-01-01 DOI:10.1177/25424823241289376
Larissa J Strath, Lingsong Meng, Yutao Zhang, Asha Rani, Zhiguang Huo, Thomas C Foster, Roger B Fillingim, Yenisel Cruz-Almeida
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Abstract

Background: Chronic pain and Alzheimer's disease (AD) are prevalent in older age and their etiologies remain to be understoodand evidence supports potential associations between the two. Both high impact pain and AD have been previously associated with differences in the epigenome. Interactions with the epigenome may serve as a possible underlying mechanism linking high impact pain and AD.

Objective: To complete epigenetic canonical pathways analyses related to AD in individuals with and without high-impact knee pain.

Methods: This manuscript aimed to explore differences in DNA methylation patterns in genes and pathways associated with AD. Blood samples of cognitively intact, community-dwelling adults with high impact knee painmversus pain-free controls were compared on their DNA methylation levels of AD-related genes. Pathway enrichment analysis was performed on significantly different DNA Methylation probes by pain group.

Results: There were significant DNA methylation differences between the high impact versus the pain-free control groups in genes and pathways associated with AD (p < 0.05). We found a total of 17,563 differentially methylated CpG probes, including 13,411 hypermethylated CpG probes and 4152 hypomethylated CpG probes. Further, pathway analysis revealed these differences were significantly associated with AD-related pathways associated with AD progression.

Conclusions: This study sample showed AD-related DNA methylation differences and associated potential canonical pathways in those with and without high impact knee pain. These results highlight the need to study overlapping epigenetic modifications underlying high impact pain and AD pathologies. Further studies, including gene expression, are needed to further explore the relationship between epigenetics, chronic pain, and AD.

认知完整个体血液中阿尔茨海默病相关基因组通路的差异DNA甲基化谱,有和没有高影响慢性疼痛
背景:慢性疼痛和阿尔茨海默病(AD)在老年人中普遍存在,其病因尚不清楚,有证据支持两者之间的潜在关联。高冲击性疼痛和AD以前都与表观基因组的差异有关。与表观基因组的相互作用可能是连接高冲击痛和AD的潜在机制。目的:完成与AD相关的表观遗传典型通路分析,在有或没有高冲击性膝关节疼痛的个体中。方法:本文旨在探讨与AD相关的基因和途径中DNA甲基化模式的差异。研究人员比较了认知完整的社区居住成年人的血液样本中ad相关基因的DNA甲基化水平,这些成年人患有高冲击性膝关节疼痛和无疼痛对照。疼痛组对差异显著的DNA甲基化探针进行通路富集分析。结果:在与AD相关的基因和途径上,高冲击组与无痛对照组之间存在显著的DNA甲基化差异(p)。结论:该研究样本显示AD相关的DNA甲基化差异和相关的潜在规范途径在有和没有高冲击膝关节疼痛的患者中。这些结果强调了研究高冲击性疼痛和AD病理的重叠表观遗传修饰的必要性。需要进一步的研究,包括基因表达,来进一步探索表观遗传学、慢性疼痛和AD之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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