Deep brain stimulation of the nucleus basalis of Meynert in severe Alzheimer's disease.

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2024-11-24 eCollection Date: 2024-01-01 DOI:10.1177/25424823241296780
Junpeng Xu, Bin Liu, Guosong Shang, Shuzhen Liu, Zhebin Feng, Haonan Yang, Di Liu, Qing Chang, Yuhan Chen, Xinguang Yu, Zhiqi Mao
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Abstract

Background: Alzheimer's disease (AD) is increasingly prevalent, leading to severe cognitive decline and a diminished quality of life for patients. Nucleus basalis of Meynert deep brain stimulation (NBM-DBS) is a potential treatment approach.

Objective: This study aims to assess the efficacy and safety of NBM-DBS for AD patients.

Methods: We conducted a clinical study involving 6 patients with severe AD who received NBM-DBS. The treatment's safety and efficacy were evaluated using cognitive function tests (Mini-Mental State Examination, Montreal Cognitive Assessment, Alzheimer's Disease Rating Scale- cognitive subscale, Clinical Dementia Rating) and assessments of neuropsychiatric symptoms and sleep disorders (Functional Activity Questionnaire, Functional Independence Measure, Zarit Burden Interview, Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, Neuropsychiatric Inventory, Pittsburgh Sleep Quality Index).

Results: NBM-DBS was safe, with no severe adverse events. It improved cognitive functions and self-care abilities without altering the disease's progression. Notably, NBM-DBS significantly alleviated neuropsychiatric symptoms and sleep disturbances.

Conclusions: NBM-DBS could be a promising therapeutic approach for severe AD, particularly for managing neuropsychiatric symptoms and sleep disorders. Further research is warranted to confirm these preliminary findings.

重度阿尔茨海默病中Meynert基底核的脑深部刺激。
背景:阿尔茨海默病(AD)越来越普遍,导致患者严重的认知能力下降和生活质量下降。Meynert基底核深部脑刺激(NBM-DBS)是一种潜在的治疗方法。目的:本研究旨在评价NBM-DBS治疗AD患者的有效性和安全性。方法:我们对6例接受NBM-DBS治疗的重度AD患者进行了临床研究。采用认知功能测试(迷你精神状态检查、蒙特利尔认知评估、阿尔茨海默病评定量表-认知亚量表、临床痴呆评分)和神经精神症状和睡眠障碍评估(功能活动问卷、功能独立性测量、Zarit负担访谈、汉密尔顿焦虑评定量表、汉密尔顿抑郁评定量表、神经精神量表、匹兹堡睡眠质量指数)。结果:NBM-DBS是安全的,无严重不良事件。它在不改变疾病进展的情况下改善了认知功能和自我照顾能力。值得注意的是,NBM-DBS显著缓解了神经精神症状和睡眠障碍。结论:NBM-DBS可能是一种很有前景的治疗重度AD的方法,特别是在治疗神经精神症状和睡眠障碍方面。有必要进一步研究以证实这些初步发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.80
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