Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.

IF 4.4 2区 医学 Q1 NEUROSCIENCES
Dixit Sharma, Shira M Lupkin, Vincent B McGinty
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Abstract

The orbitofrontal cortex (OFC) plays a crucial role in value-based decisions. While much is known about how OFC neurons represent values, far less is known about information encoded in OFC local field potentials (LFPs). LFPs are important because they can reflect subthreshold activity not directly coupled to spiking and because they are potential targets for less invasive forms of brain-machine interface (BMI). We recorded neural activity in the OFC of male macaques performing a two-option value-based decision task. We compared the value- and decision-coding properties of high-gamma LFPs (HG, 50-150 Hz) to the coding properties of spiking multiunit activity (MUA) recorded concurrently on the same electrodes. HG and MUA both represented the values of decision targets, but HG signals had value-coding features that were distinct from concurrently measured MUA. On average HG amplitude increased monotonically with value, whereas in MUA the value encoding was net neutral on average. HG encoded a signal consistent with a comparison between target values, a signal which was negligible in MUA. In individual channels, HG could predict choice outcomes more accurately than MUA; however, when channels were combined in a population-based decoder, MUA was more accurate than HG. In summary, HG signals reveal value-coding features in OFC that could not be observed from spiking activity, including representation of value comparisons and more accurate behavioral predictions. These results have implications for the role of OFC in value-based decisions and suggest that high-frequency LFPs may be a viable-or even preferable-target for BMIs to assist cognitive function.

眶额部高伽马反映了峰值可解离值和决策机制。
眶额皮质(OFC)在基于价值的决策中起着至关重要的作用。虽然我们对OFC神经元如何表示值有很多了解,但对OFC局部场电位(LFPs)编码的信息知之甚少。lfp很重要,因为它们可以反映与尖峰不直接相关的阈下活动,而且它们是侵入性较小的脑机接口(BMI)的潜在目标。我们记录了雄性猕猴在执行一个基于两种选择值的决策任务时OFC的神经活动。我们比较了高伽马lfp (HG, 50-150 Hz)与在同一电极上同时记录的尖峰多单位活动(MUA)的编码特性。HG和MUA都表示决策目标的值,但HG信号具有不同于并发测量MUA的值编码特征。平均HG振幅随值单调增加,而MUA值编码平均为净中性。HG编码了一个与目标值比较一致的信号,这个信号在MUA中可以忽略不计。在个体渠道中,HG比MUA更能准确地预测选择结果;然而,当信道组合在基于人群的解码器中时,MUA比HG更准确。总之,HG信号揭示了OFC中无法从峰值活动中观察到的值编码特征,包括值比较的表示和更准确的行为预测。这些结果暗示了OFC在基于价值的决策中的作用,并表明高频lfp可能是bmi辅助认知功能的可行目标,甚至是更好的目标。高频lfp通常被认为仅仅是局部尖峰活动的代理。这项研究在猴子做出基于价值的决策的OFC中发现了相反的证据。在决策机制方面,研究结果挑战了之前的发现,表明OFC在计算值比较中的作用,这在HG编码的比较信号中很明显,但没有尖峰。更广泛地说,这些结果为前额叶皮层中突波/LFP分离的证据提供了新的证据,并支持了HG信号是识别认知任务中神经计算的重要但被忽视的资源的观点。此外,单通道HG信号提供了更准确的选择行为预测,支持HG信号在认知神经修复中的潜在应用。
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来源期刊
Journal of Neuroscience
Journal of Neuroscience 医学-神经科学
CiteScore
9.30
自引率
3.80%
发文量
1164
审稿时长
12 months
期刊介绍: JNeurosci (ISSN 0270-6474) is an official journal of the Society for Neuroscience. It is published weekly by the Society, fifty weeks a year, one volume a year. JNeurosci publishes papers on a broad range of topics of general interest to those working on the nervous system. Authors now have an Open Choice option for their published articles
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