Roy Khalaf, UYeong Choi, Connor Prosty, Moshe Ben-Shoshan
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引用次数: 0
Abstract
Background: Serum sickness-like reaction (SSLR) is an adverse reaction mainly to drugs/infectious agents/ vaccines, characterized by the presence of rash, arthralgia/arthritis and occasionally fever.
Objective: This systematic review aimed to analyze the clinical characteristics, implicated agents, symptomatology, and management of SSLR.
Methods: A systematic review was conducted following PRISMA guidelines. Case reports and case series were included due to the paucity of data in the literature on SSLR. A comprehensive search of Embase and MedLine was performed. Data extracted included age, comorbidities, medication exposure, time to reaction, symptoms, diagnostic criteria, and treatment modalities. Descriptive statistics were employed to summarize the data. Chi Square test was used to compare categorical variables between adults and children.
Results: Forty-four studies comprising 468 patients were included. Antibiotics were more associated with SSLR in children than in adults (P<0.01). Beta-lactam antibiotics, particularly amoxicillin (72.1%), were the leading implicated agents. Dermatological manifestations, primarily maculopapular rashes, were present in 100.0% of cases, while joint symptoms occurred in 78.7%. Corticosteroids were effective in resolving symptoms in most cases.
Conclusion: SSLR presents diagnostic challenges due to overlapping symptoms with other drug reactions. Beta-lactams are the most common implicated agents, particularly in pediatric populations. Systemic corticosteroids may provide relief, but standardized guidelines for diagnosis and management are needed. Further research is essential to clarify the pathophysiology and optimize treatment strategies for SSLR.
期刊介绍：
JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases.
This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders.
The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.
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