Generating Inhibitory Neuron Diversity through Morphogenic Patterning: From in vivo Studies to New in vitro Models.

IF 2.3 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Developmental Neuroscience Pub Date : 2025-03-03 DOI:10.1159/000545031

Tanya Deutsch Guerrero, Chloé Borowski, Julien Ferent

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引用次数: 0

Abstract

Background: The proper functioning of the central nervous system depends on the cooperation of distinct neuronal subtypes generated during development.

Summary: Here, we review new insights provided by recent research and technological advances into the mechanisms underlying the generation of the remarkable diversity of inhibitory GABAergic neurons (INs). INs are generated in the ventral telencephalon or subpallium and migrate long distances to populate multiple brain regions. INs exhibit considerable morphological, molecular, and electrophysiological diversity. This diversity is mediated by intrinsic and extrinsic factors, including secreted molecules (such as sonic hedgehog).

Key messages: This review examines the role of extrinsic factors in the establishment of distinct subpallial domains and the subsequent emergence of IN diversity. We begin by summarizing the in vivo morphogenesis of this process and then highlight the new technologies that allow us to revisit the role of morphogens in subpallial development and IN specification.

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通过形态发生模式产生抑制性神经元多样性：从体内研究到新型体外模型

中枢神经系统的正常功能依赖于发育过程中产生的不同神经元亚型的合作。在这里，我们回顾了最近的研究和技术进步对抑制性GABAergic神经元（INs）多样性产生机制的新见解。INs产生于端脑腹侧或皮层下，并远距离迁移到多个脑区。INs表现出相当大的形态、分子和电生理多样性。这种多样性是由内在和外在因素介导的，包括分泌分子（如Sonic Hedgehog）。这篇综述探讨了外在因素在建立不同的pallial下域和随后出现的in多样性中的作用。我们首先总结了这一过程的体内形态发生，然后强调了新技术，使我们能够重新审视形态发生在pallial下发育和in规范中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Neuroscience 医学-发育生物学

CiteScore

4.00

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.