{"title":"The effect of oral nutrition on diabetic ketoacidosis resolution time: Retrospective Cohort study.","authors":"Başak Can, Zeynep Karaali","doi":"10.1007/s12020-025-04204-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic ketoacidosis (DKA) is a serious disease that requires urgent and aggressive intervention. Although the medical treatments and protocols are well established, the role of oral nutrition during DKA treatment remains unclear. We aimed to evaluate the effect of oral nutritional status on the resolution rate of DKA.</p><p><strong>Material and methods: </strong>This retrospective cohort study is a single-centre study consisting of patients who were admitted with a diagnosis of DKA and were followed up in the ward. Patients were divided into two groups based on their oral nutrition status. The first group consisted of patients who received open oral nutrition during DKA treatment. The second group consisted of patients whose oral feeding was stopped until DKA resolved. Factors such as diabetes-related characteristics, DKA resolution time, and length of hospital stay were compared between the groups. The Chi-square test and Mann-Whitney U test were used for comparisons between groups.</p><p><strong>Results: </strong>Of the 51 DKA patients evaluated, 29 were in the open oral feeding group, while there were 22 patients in the oral feeding stopped group. The recovery time for DKA was 9.9 ± 9.1 h in the oral nutrition group and 20.2 ± 13.7 h in the oral nutrition stopped group (p < 0.001). The mean length of hospital stay was 5.9 ± 3.3 days in the oral nutrition group and 7.4 ± 5.9 days in the oral nutrition stopped group (p = 0.346). The mean anion gap normalization time was 12.5 ± 8.6 h in the open oral feeding group and, 22.6 ± 14 h in the oral feeding stopped group (p < 0.001).</p><p><strong>Conclusion: </strong>Oral nutrition until DKA resolves allows the patient to recover more quickly and have a shorter hospital stay. These findings suggest a relationship between oral nutrition and faster DKA recovery.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-025-04204-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
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Abstract
Purpose: Diabetic ketoacidosis (DKA) is a serious disease that requires urgent and aggressive intervention. Although the medical treatments and protocols are well established, the role of oral nutrition during DKA treatment remains unclear. We aimed to evaluate the effect of oral nutritional status on the resolution rate of DKA.
Material and methods: This retrospective cohort study is a single-centre study consisting of patients who were admitted with a diagnosis of DKA and were followed up in the ward. Patients were divided into two groups based on their oral nutrition status. The first group consisted of patients who received open oral nutrition during DKA treatment. The second group consisted of patients whose oral feeding was stopped until DKA resolved. Factors such as diabetes-related characteristics, DKA resolution time, and length of hospital stay were compared between the groups. The Chi-square test and Mann-Whitney U test were used for comparisons between groups.
Results: Of the 51 DKA patients evaluated, 29 were in the open oral feeding group, while there were 22 patients in the oral feeding stopped group. The recovery time for DKA was 9.9 ± 9.1 h in the oral nutrition group and 20.2 ± 13.7 h in the oral nutrition stopped group (p < 0.001). The mean length of hospital stay was 5.9 ± 3.3 days in the oral nutrition group and 7.4 ± 5.9 days in the oral nutrition stopped group (p = 0.346). The mean anion gap normalization time was 12.5 ± 8.6 h in the open oral feeding group and, 22.6 ± 14 h in the oral feeding stopped group (p < 0.001).
Conclusion: Oral nutrition until DKA resolves allows the patient to recover more quickly and have a shorter hospital stay. These findings suggest a relationship between oral nutrition and faster DKA recovery.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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