ChaoRui Wang, HuiLin Peng, XiuWen Yuan, HeWei Ji, YongNan Xu, Nam-Hyung Kim, YingHua Li
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引用次数: 0
Abstract
Neonicotinoid insecticides (NEOs) are the most widely used pesticides in modern agriculture, and there are residues in the environment and food. Thiamethoxam (TMX) has been proven to destroy the ovarian homeostasis of mice in vivo and reduce the development of porcine oocytes in vitro. However, whether TMX can interfere with porcine oocyte maturation and its potential mechanism remains unknown. This study indicated that TMX affects the expansion of cumulus cells, destroys the balance of lipid metabolism, and damages mitochondrial function. TMX treatment decreased the expression of genes related to cumulus cell expansion, lipid synthesis and mitochondrial synthesis. Collectively, results confirm that TMX exposure can damage oocyte maturation and produce reproductive toxicity by inducing lipid metabolism and mitochondrial dysfunction in porcine.
期刊介绍：
The journal offers comprehensive information concerning physiology, pathology, and biotechnology of reproduction. Topical results are currently published in original papers, reviews, and short communications with particular attention to investigations on practicable techniques.
Carefully selected reports, e. g. on embryo transfer and associated biotechnologies, gene transfer, and spermatology provide a link between basic research and clinical application. The journal applies to breeders, veterinarians, and biologists, and is also of interest in human medicine. Interdisciplinary cooperation is documented in the proceedings of the joint annual meetings.
Fields of interest: Animal reproduction and biotechnology with special regard to investigations on applied and clinical research.
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