Stromal Prognostic Markers for Oral Cancer: An Update.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-03-03 DOI:10.1111/odi.15278

Everton Freitas de Morais, Antti Mäkitie, Ricardo D Coletta, Alhadi Almangush

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引用次数: 0

Abstract

Background: This article aims to provide a broad overview of the oral squamous cell carcinoma (OSCC) tumor stroma, describing and discussing recent advances in the understanding of different stromal elements and their roles in tumor progression. We also describe potential new therapeutic approaches targeting the stroma.

Methods: A literature review on the role of stromal biomarkers in OSCC was conducted. A narrative overview of current literature was undertaken to synthesize the contexts with elaboration and summary.

Results: The crosstalk between cancer cells and the tumor stroma, a major driver of tumor progression and metastasis, has increasingly been unveiled. This review highlights the tumor-to-stroma ratio (TSR) as a valuable prognostic marker in OSCC, with high stromal content (TSR > 50%) linked to poorer survival. On the other hand, tumor-infiltrating lymphocytes are associated with improved prognosis and longer survival. Furthermore, emerging markers, such as cancer-associated fibroblasts and desmoplastic reactions, play significant roles in promoting tumor invasiveness and resistance to therapy. The review identifies gaps in current evidence and proposes directions for future research to further clarify the prognostic utility of stromal components.

Conclusions: Stromal markers provide valuable prognostic insights into OSCC and could enhance clinical decision-making, emphasizing the complexity of OSCC progression.

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口腔癌间质预后标志物：最新进展。

背景：本文旨在提供口腔鳞状细胞癌（OSCC）肿瘤间质的广泛概述，描述和讨论不同间质成分及其在肿瘤进展中的作用的最新进展。我们还描述了针对基质的潜在的新治疗方法。方法：回顾有关间质生物标志物在OSCC中的作用的文献。对当前文献进行了叙述性概述，以阐述和总结综合上下文。结果：肿瘤细胞与肿瘤间质间的串扰是肿瘤进展和转移的主要驱动因素，目前已被越来越多地揭示。本综述强调肿瘤与间质比（TSR）是OSCC的一个有价值的预后指标，高间质含量（TSR为50%）与较差的生存率相关。另一方面，肿瘤浸润淋巴细胞与改善预后和延长生存期有关。此外，新兴的标志物，如癌症相关的成纤维细胞和结缔组织增生反应，在促进肿瘤侵袭和对治疗的抵抗中发挥了重要作用。这篇综述指出了目前证据中的差距，并提出了未来研究的方向，以进一步阐明基质成分的预后效用。结论：间质标志物为OSCC的预后提供了有价值的见解，可以增强临床决策，强调OSCC进展的复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.