Vascular actions of Ang 1–7 and Ang 1–8 through EDRFs and EDHFs in non-diabetes and diabetes mellitus

IF 3.2 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Nazar M. Shareef Mahmood, Almas M.R. Mahmud, Ismail M. Maulood
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引用次数: 0

Abstract

The renin-angiotensin system (RAS) plays a pivotal role in regulating vascular homeostasis, while angiotensin 1-8 (Ang 1–8) traditionally dominates as a vasoconstrictor factor. However, the discovery of angiotensin 1-7 (Ang 1–7) and Ang 1–8 has revealed counter-regulatory mechanisms mediated through endothelial-derived relaxing factors (EDRFs) and endothelial-derived hyperpolarizing factors (EDHFs). This review delves into the vascular actions of Ang 1–7 and Ang 1–8 in both non-diabetes mellitus (non-DM) and diabetes mellitus (DM) conditions, highlighting their effects on vascular endothelial cell (VECs) function as well. In a non-DM vasculature context, Ang 1–8 demonstrate dual effect including vasoconstriction and vasodilation, respectively. Additionally, Ang 1–7 induces vasodilation upon nitric oxide (NO) production as a prominent EDRFs in distinct mechanisms. Further research elucidating the precise mechanisms underlying the vascular actions of Ang 1–7 and Ang 1–8 in DM will facilitate the development of tailored therapeutic interventions aimed at preserving vascular health and preventing cardiovascular complications.
在非糖尿病和糖尿病患者中,Ang 1-7和Ang 1-8通过EDRFs和EDHFs在血管中的作用。
肾素-血管紧张素系统(RAS)在调节血管稳态中起关键作用,而血管紧张素1-8 (Ang 1-8)传统上作为血管收缩因子占主导地位。然而,血管紧张素1-7 (Ang 1-7)和Ang 1-8的发现揭示了通过内皮源性松弛因子(edrf)和内皮源性超极化因子(EDHFs)介导的反调控机制。本文综述了Ang 1-7和Ang 1-8在非糖尿病(non-DM)和糖尿病(DM)条件下的血管作用,以及它们对血管内皮细胞(VECs)功能的影响。在非糖尿病血管情况下,Ang 1-8分别表现出血管收缩和血管舒张的双重作用。此外,Ang 1-7作为一种突出的EDRFs,以不同的机制诱导一氧化氮(NO)产生时的血管舒张。进一步研究阐明Ang 1-7和Ang 1-8在糖尿病中血管作用的确切机制,将有助于开发针对性的治疗干预措施,旨在保护血管健康和预防心血管并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nitric oxide : biology and chemistry
Nitric oxide : biology and chemistry 生物-生化与分子生物学
CiteScore
7.50
自引率
7.70%
发文量
74
审稿时长
52 days
期刊介绍: Nitric Oxide includes original research, methodology papers and reviews relating to nitric oxide and other gasotransmitters such as hydrogen sulfide and carbon monoxide. Special emphasis is placed on the biological chemistry, physiology, pharmacology, enzymology and pathological significance of these molecules in human health and disease. The journal also accepts manuscripts relating to plant and microbial studies involving these molecules.
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