Expression of Serum Inflammatory Factors in Patients with Acute Ischemic Stroke Complicated with Type 2 Diabetes Mellitus and Its Relationship with the Formation and Stability of Carotid Atherosclerotic Plaque.

Abstract

To explore the stability of carotid plaques and their relationship with biomarkers in patients with acute ischemic stroke (AIS) complicated with type 2 diabetes mellitus (T2DM). A retrospective analysis was conducted on 160 cases of AIS patients with T2DM. They were divided into plaque group, intima thickening group (CG), and normal intima group (DG). 95 plaque patients were grouped: stable plaque group (AG) and unstable plaque group (BG). Serum indicators and carotid intima-media thickness (IMT) were collated, and Pearson correlation analysis (PCA) and multiple logistic regression analysis (MLRA) were performed. As against CG, AG and BG had higher levels of high-sensitivity C-reactive protein (hs-CRP), homocysteine (HCY), and IMT (P < 0.05). The carotid IMT in patients suggested an obvious positive correlation with hs-CRP and HCY (P < 0.001). Hs-CRP and HCY had an obvious positive impact on the formation of carotid plaques; as against AG, BG had higher levels of hs-CRP, HCY, total cholesterol (TC), and IMT (P < 0.05). The stability of patients' carotid arteries suggested an obvious positive correlation with hs-CRP and TC (P < 0.05), and HCY (P < 0.001). The levels of hs-CRP, TC, and HCY had an obvious positive impact on the IMT of patients (P < 0.05). High levels of hs-CRP, TC, and HCY have a positive impact on the stability of carotid plaques and are independent risk factors for plaque instability.