Biological properties of activated bentonite vs. non-activated bentonite in mice fed an aflatoxin-contaminated diet: a comparative investigation.

IF 2.6 4区 医学 Q2 MYCOLOGY
Faezeh Oskoueian, Seyedeh Fatemeh Hosseini, Hadis Honarvar Seddighian, Sahar Abdi, Yeganeh Jalalian, Yeganeh Babayan Mashhadi, Ehsan Oskoueian, Ehsan Karimi, Mohammad Faseleh Jahromi, Parisa Shokryazdan, Mojtaba Moein Jahromi
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Abstract

Aflatoxins are mycotoxins produced by certain molds, especially Aspergillus species, which are commonly found in nature. These toxins can contaminate animal feed and lead to aflatoxicosis in various livestock species. It has been proposed that using bentonite could help alleviate the symptoms of aflatoxicosis. Recent research, however, has highlighted the importance of the activation process in enhancing bentonite's inhibitory activity against aflatoxicosis. To further investigate this, 40 mice were randomly divided into four dietary groups: a control diet, an aflatoxins-contaminated diet (2 mg/kg), an aflatoxins-contaminated diet supplemented with 2 mg/kg diet and inactive bentonite (5 g/kg diet), and an aflatoxins-contaminated diet supplemented with 2 mg/kg diet and activated bentonite (5 g/kg diet) for 4 weeks. The results demonstrated that bentonite activation improved its specific surface area and total pore volume. Additionally, aflatoxins significantly negatively impacted various parameters such as average daily weight gain, food intake, liver enzymes, serum redox potential, morphometric characteristics of the jejunum, and induced hepatic inflammation. The study found that the dietary addition of both non-activated and activated bentonite significantly improved these parameters. However, activated bentonite displayed greater potency in alleviating the symptoms of aflatoxicosis compared to non-activated bentonite. As a result, it is recommended to use activated bentonite when dealing with aflatoxin contamination in animal diets.

黄曲霉毒素污染小鼠饲料中活化膨润土与非活化膨润土生物学特性的比较研究。
黄曲霉毒素是由某些霉菌,特别是曲霉产生的真菌毒素,在自然界中很常见。这些毒素可以污染动物饲料,并导致各种牲畜黄曲霉中毒。有人提出,使用膨润土可以帮助缓解黄曲霉中毒的症状。然而,最近的研究强调了活化过程在增强膨润土对黄曲霉中毒的抑制活性中的重要性。为此,将40只小鼠随机分为4组:对照组、黄曲霉毒素污染组(2 mg/kg)、黄曲霉毒素污染组(添加2 mg/kg饲料和无活性膨润土组(5 g/kg饲料)、黄曲霉毒素污染组(添加2 mg/kg饲料和活性膨润土组(5 g/kg饲料),持续4周。结果表明,膨润土活化提高了膨润土的比表面积和总孔容。此外,黄曲霉毒素对平均日增重、食物摄入量、肝酶、血清氧化还原电位、空肠形态特征和诱导的肝脏炎症等参数均有显著的负面影响。研究发现,饲粮中添加非活化和活化膨润土均能显著改善这些参数。然而,与非活化膨润土相比,活化膨润土在缓解黄曲霉中毒症状方面表现出更大的效力。因此,在处理动物饲料中的黄曲霉毒素污染时,建议使用活性膨润土。
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来源期刊
Mycotoxin Research
Mycotoxin Research MYCOLOGYTOXICOLOGY-TOXICOLOGY
CiteScore
6.40
自引率
6.70%
发文量
29
期刊介绍: Mycotoxin Research, the official publication of the Society for Mycotoxin Research, is a peer-reviewed, scientific journal dealing with all aspects related to toxic fungal metabolites. The journal publishes original research articles and reviews in all areas dealing with mycotoxins. As an interdisciplinary platform, Mycotoxin Research welcomes submission of scientific contributions in the following research fields: - Ecology and genetics of mycotoxin formation - Mode of action of mycotoxins, metabolism and toxicology - Agricultural production and mycotoxins - Human and animal health aspects, including exposure studies and risk assessment - Food and feed safety, including occurrence, prevention, regulatory aspects, and control of mycotoxins - Environmental safety and technology-related aspects of mycotoxins - Chemistry, synthesis and analysis.
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