{"title":"Biological properties of activated bentonite vs. non-activated bentonite in mice fed an aflatoxin-contaminated diet: a comparative investigation.","authors":"Faezeh Oskoueian, Seyedeh Fatemeh Hosseini, Hadis Honarvar Seddighian, Sahar Abdi, Yeganeh Jalalian, Yeganeh Babayan Mashhadi, Ehsan Oskoueian, Ehsan Karimi, Mohammad Faseleh Jahromi, Parisa Shokryazdan, Mojtaba Moein Jahromi","doi":"10.1007/s12550-025-00584-3","DOIUrl":null,"url":null,"abstract":"<p><p>Aflatoxins are mycotoxins produced by certain molds, especially Aspergillus species, which are commonly found in nature. These toxins can contaminate animal feed and lead to aflatoxicosis in various livestock species. It has been proposed that using bentonite could help alleviate the symptoms of aflatoxicosis. Recent research, however, has highlighted the importance of the activation process in enhancing bentonite's inhibitory activity against aflatoxicosis. To further investigate this, 40 mice were randomly divided into four dietary groups: a control diet, an aflatoxins-contaminated diet (2 mg/kg), an aflatoxins-contaminated diet supplemented with 2 mg/kg diet and inactive bentonite (5 g/kg diet), and an aflatoxins-contaminated diet supplemented with 2 mg/kg diet and activated bentonite (5 g/kg diet) for 4 weeks. The results demonstrated that bentonite activation improved its specific surface area and total pore volume. Additionally, aflatoxins significantly negatively impacted various parameters such as average daily weight gain, food intake, liver enzymes, serum redox potential, morphometric characteristics of the jejunum, and induced hepatic inflammation. The study found that the dietary addition of both non-activated and activated bentonite significantly improved these parameters. However, activated bentonite displayed greater potency in alleviating the symptoms of aflatoxicosis compared to non-activated bentonite. As a result, it is recommended to use activated bentonite when dealing with aflatoxin contamination in animal diets.</p>","PeriodicalId":19060,"journal":{"name":"Mycotoxin Research","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mycotoxin Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12550-025-00584-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MYCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aflatoxins are mycotoxins produced by certain molds, especially Aspergillus species, which are commonly found in nature. These toxins can contaminate animal feed and lead to aflatoxicosis in various livestock species. It has been proposed that using bentonite could help alleviate the symptoms of aflatoxicosis. Recent research, however, has highlighted the importance of the activation process in enhancing bentonite's inhibitory activity against aflatoxicosis. To further investigate this, 40 mice were randomly divided into four dietary groups: a control diet, an aflatoxins-contaminated diet (2 mg/kg), an aflatoxins-contaminated diet supplemented with 2 mg/kg diet and inactive bentonite (5 g/kg diet), and an aflatoxins-contaminated diet supplemented with 2 mg/kg diet and activated bentonite (5 g/kg diet) for 4 weeks. The results demonstrated that bentonite activation improved its specific surface area and total pore volume. Additionally, aflatoxins significantly negatively impacted various parameters such as average daily weight gain, food intake, liver enzymes, serum redox potential, morphometric characteristics of the jejunum, and induced hepatic inflammation. The study found that the dietary addition of both non-activated and activated bentonite significantly improved these parameters. However, activated bentonite displayed greater potency in alleviating the symptoms of aflatoxicosis compared to non-activated bentonite. As a result, it is recommended to use activated bentonite when dealing with aflatoxin contamination in animal diets.
期刊介绍:
Mycotoxin Research, the official publication of the Society for Mycotoxin Research, is a peer-reviewed, scientific journal dealing with all aspects related to toxic fungal metabolites. The journal publishes original research articles and reviews in all areas dealing with mycotoxins. As an interdisciplinary platform, Mycotoxin Research welcomes submission of scientific contributions in the following research fields:
- Ecology and genetics of mycotoxin formation
- Mode of action of mycotoxins, metabolism and toxicology
- Agricultural production and mycotoxins
- Human and animal health aspects, including exposure studies and risk assessment
- Food and feed safety, including occurrence, prevention, regulatory aspects, and control of mycotoxins
- Environmental safety and technology-related aspects of mycotoxins
- Chemistry, synthesis and analysis.