Effects of memantine and donepezil on social memory, anxiety-like behavior and the expression levels of microRNA-124, microRNA-125b, and microRNA-132 in scopolamine-induced memory impairment in rats.

IF 1.7 4区 医学 Q3 CLINICAL NEUROLOGY
Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-03-03 DOI:10.1080/01616412.2025.2472848
Pouria Bahmani Kolour, Hamed Ghazvini, Mobin Naderi, Hossein Ghalehnoei, Masoumeh Rezaei Talarposhti
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引用次数: 0

Abstract

Introduction: Almost all physiological processes are modulated by microRNAs, therefore, dysregulation of these small regulatory RNAs is observed in a variety of diseases, including cognitive impairments.

Methods: In this study, 40 male Wistar rats were randomly divided into five groups of control, scopolamine, donepezil, memantine, and combined administration of donepezil + memantine. Rats in scopolamine, donepezil, memantine, and combined administration of donepezil + memantine groups received scopolamine (1 mg/kg-intraperitoneal) for 7 days. After the last administration of scopolamine, was started injecting donepezil (3 mg/kg-i.p.), memantine (10 mg/kg-i.p.), and combined administration of Donepezil + Memantine (0.5 mg/kg and 5 mg/kg-i.p., respectively), up to 21 days. Twenty-four hours after the last injection, elevated plus-maze, social interaction, open field tests, and gene expression analysis of miR-124, miR-125b, and miR-132 in the hippocampus were carried out.

Results: The results of the behavioral tests indicate that donepezil and memantine significantly prevented Scopolamine-induced anxiety, sociability, and social memory decline. The gene expression of selected microRNAs did not significantly differ between the groups.

Discussion: This study revealed that donepezil and memantine effectively prevent synaptic plasticity disruption and cognitive decline induced by scopolamine. Findings indicated that this treatment is unrelated to the expression of the selected microRNAs. The positive effects of memantine and donepezil depend on age, dosages, cognitive task demands, and possibly the length and timing of the treatment.

美金刚和多奈哌齐对东莨菪碱致记忆障碍大鼠社交记忆、焦虑样行为及microRNA-124、microRNA-125b和microRNA-132表达水平的影响
导读:几乎所有的生理过程都是由microRNAs调节的,因此,在包括认知障碍在内的多种疾病中都观察到这些小调控rna的失调。方法:将40只雄性Wistar大鼠随机分为对照组、东莨菪碱组、多奈哌齐组、美金刚组和多奈哌齐+美金刚组。东莨菪碱、多奈哌齐、美金刚及多奈哌齐+美金刚联合给药组大鼠给予东莨菪碱(1mg /kg-腹腔注射)7 d。末次给药东莨菪碱后,开始注射多奈哌齐(3mg /kg-i.p)、美金刚(10mg /kg-i.p),多奈哌齐+美金刚(0.5 mg/kg、5mg /kg-i.p)联合给药。),最长可达21天。末次注射24小时后,进行海马区miR-124、miR-125b、miR-132的升高+迷宫、社会互动、开放场试验和基因表达分析。结果:行为测试结果显示,多奈哌齐和美金刚能显著预防东莨菪碱引起的焦虑、社交能力和社会记忆下降。所选microrna的基因表达在两组间无显著差异。讨论:本研究发现,多奈哌齐和美金刚能有效预防东莨菪碱引起的突触可塑性破坏和认知能力下降。研究结果表明,这种治疗与所选择的microrna的表达无关。美金刚和多奈哌齐的积极作用取决于年龄、剂量、认知任务要求,可能还取决于治疗的时间和时间。
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来源期刊
Neurological Research
Neurological Research 医学-临床神经学
CiteScore
3.60
自引率
0.00%
发文量
116
审稿时长
5.3 months
期刊介绍: Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.
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