The Impact of Frequency of Cannabis Use on Hypertensive Disorders During Pregnancy.

IF 4.2 3区医学 Q1 SUBSTANCE ABUSE

Journal of Addiction Medicine Pub Date : 2025-03-03 DOI:10.1097/ADM.0000000000001454

Nichole Nidey, Erica Raff, Md Tareq Ferdous Khan, Shannon Lea Watkins, Jennifer M Jm McAllister, Laura Kair, Mishka Terplan, Andrea Greiner

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引用次数: 0

Abstract

Objectives: Cannabis is 1 of the most commonly used substances during pregnancy, and there is mixed evidence of its impact on maternal outcomes, such as hypertensive disorders. Prior research on cannabis use during pregnancy has not accounted for use frequency, which might explain mixed results across studies. The objective of this study was to examine how frequencies of use during pregnancy are associated with hypertensive disorders.

Methods: This was a retrospective cohort study of the 2017-2018 Pregnancy Risk Assessment Monitoring System survey (n = 10,911/weighted n = 587,486). Frequency of cannabis use was categorized for analysis as follows: no use, minimal use (1 time per month or less), moderate use (2 times per month to 1 day per week), and frequent use (2-6 times per week to daily). Multivariable logistic regression models were used to examine how the frequency of cannabis use influenced the odds of experiencing hypertensive disorders during pregnancy.

Results: Cannabis use, measured as a binary exposure variable (yes/no), was not associated with higher odds of hypertension during pregnancy (odds ratio, 0.86; 95% confidence interval, 0.54, 1.35). However, among those with any cannabis use, frequent use (vs minimal use) was associated with higher odds of hypertensive disorders (odds ratio, 3.44; confidence interval, 1.40, 8.43).

Conclusions: Identifying cannabis use frequency during pregnancy can help identify maternal risk of hypertensive disorders.

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妊娠期大麻使用频率对高血压疾病的影响。

目的：大麻是怀孕期间最常用的物质之一，有各种各样的证据表明它对产妇结局的影响，如高血压疾病。之前关于怀孕期间使用大麻的研究并没有考虑到使用频率，这可能解释了不同研究的不同结果。本研究的目的是检查妊娠期间使用频率与高血压疾病的关系。方法：对2017-2018年妊娠风险评估监测系统调查（n = 10,911/加权n = 587,486）进行回顾性队列研究。大麻使用频率分类如下：不使用、最少使用（每月1次或更少）、适度使用（每月2次至每周1天）和频繁使用（每周2-6次至每天）。使用多变量逻辑回归模型来检查大麻使用频率如何影响怀孕期间高血压疾病的几率。结果：大麻的使用，作为一个二元暴露变量（是/否），与怀孕期间高血压的高几率无关(优势比，0.86；95%置信区间，0.54,1.35)。然而，在有大麻使用的人群中，频繁使用（相对于少量使用）与高血压疾病的风险较高相关(优势比，3.44；置信区间，1.40,8.43)。结论：确定孕期大麻使用频率有助于确定孕妇高血压疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Addiction Medicine 医学-药物滥用

CiteScore

6.10

自引率

9.10%

发文量

260

审稿时长

>12 weeks

期刊介绍： The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.