Efficacy of erector spinae plane block for postoperative analgesia after percutaneous nephrolithotomy: A systematic review and meta-analysis of randomized controlled trials.

IF 1.5 Q3 PHARMACOLOGY & PHARMACY
Ajay Singh, Aditya Prakash Sharma, Venkata Ganesh, Rekha Gupta, Gopal Sharma, Naveen B Naik, Priyanka Sethi, Narender Kaloria, Prerna Varma
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Abstract

Introduction: Erector spinae plane block (ESPB) is a relatively newer approach to the paraspinal fascial plane block. The analgesic efficacy of this block is presently being established in percutaneous nephrolithotomy (PCNL). This meta-analysis was designed to assess the effectiveness of ESPB as a perioperative analgesic technique when compared with conventional analgesia (control) in PCNL.

Material and methods: We performed a systematic review and meta-analysis on the use of ESPB for perioperative analgesia in PCNL for renal stone disease. A systematic literature search was conducted in PubMed, Scopus, ProQuest, and EMBASE using the terms ((erector spinae plane block) AND ((Analgesia) OR (visual analogue scale) OR (VAS) OR (opioid*) OR (morphine) OR (tramadol))) AND ((percutaneous nephrolithotomy) OR (PCNL)) with an intention to include all the randomized studies comparing ESPB with the control group. The risk of bias was assessed using RoB2.

Results: A total of 187 records were identified and after the exclusions, a total of 10 trials (560 patients, 503 for primary outcome) were included. Pain scores were significantly lower in the ESPB group as compared to the control group except at the 12th postoperative hour. There were significantly better pain scores at 24 h in the ESPB group as compared to the control group (Standardized mean difference (SMD) -0.46, 95% CI (-1.05, 0.13), moderate GRADE evidence). The total opioid consumption was significantly lower in the ESPB group (SMD -1.50, 95% CI (-1.7 to -1.29, moderate GRADE evidence).

Conclusions: ESPB is more effective than conventional analgesia in terms of postoperative opioid consumption after PCNL. Future studies should incorporate better double-blinding techniques, transparent reporting of methods, and sham controls (such as additional dressing post general anesthesia) which were lacking in the current studies.

竖脊肌平面阻滞对经皮肾镜取石术后镇痛的疗效:随机对照试验的系统回顾和荟萃分析。
直立脊柱平面阻滞(ESPB)是一种相对较新的椎旁筋膜平面阻滞方法。目前正在经皮肾镜取石术(PCNL)中建立这种阻滞的镇痛效果。本荟萃分析旨在评估ESPB作为PCNL围手术期镇痛技术与常规镇痛(对照)相比的有效性。材料和方法:我们对ESPB用于肾结石PCNL患者围手术期镇痛进行了系统回顾和荟萃分析。在PubMed、Scopus、ProQuest和EMBASE中系统检索文献,检索词为(竖脊平面阻滞)、(镇痛)、(视觉模拟量表)、(VAS)、(阿片类药物*、(吗啡)、(曲马多)、(经皮肾镜取石术)、(PCNL),目的是纳入所有比较ESPB与对照组的随机研究。使用RoB2评估偏倚风险。结果:共纳入187条记录,排除后共纳入10项试验(560例患者,503例为主要结局)。除术后第12小时外,ESPB组疼痛评分明显低于对照组。与对照组相比,ESPB组24 h疼痛评分明显更好(标准化平均差(SMD) -0.46, 95% CI(-1.05, 0.13),中度GRADE证据)。ESPB组的阿片类药物总消耗量显著降低(SMD -1.50, 95% CI(-1.7至-1.29,中等GRADE证据)。结论:在PCNL术后阿片类药物消耗方面,ESPB比常规镇痛更有效。未来的研究应纳入更好的双盲技术、透明的方法报告和假对照(如全身麻醉后额外敷料),这是目前研究中所缺乏的。
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来源期刊
CiteScore
1.90
自引率
6.70%
发文量
129
期刊介绍: The JOACP publishes original peer-reviewed research and clinical work in all branches of anaesthesiology, pain, critical care and perioperative medicine including the application to basic sciences. In addition, the journal publishes review articles, special articles, brief communications/reports, case reports, and reports of new equipment, letters to editor, book reviews and obituaries. It is international in scope and comprehensive in coverage.
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