Xiexin Tang restores gut barrier function by regulating the differentiation of CD4⁺ T cells via GPRs and HDACs in T2DM rats.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-03-03 DOI:10.1080/10286020.2025.2459603

Mei-Juan Liu, Yun Zhang, Ke Zhu, Wen-Wen Li, Chen Liu, Shu Jiang, Er-Xin Shang, Jin-Ao Duan

引用次数: 0

Abstract

This study aimed to explore the potential mechanism of Xiexin Tang in improving type 2 diabetes mellitus from the perspective of intestinal barrier function. The results indicated that Xiexin Tang could notably promote the expression of GPRs while suppressing the expression of HDACs in colon epithelial cells, then significantly elevate the levels of TGF-β1 and IL-18 to regulate the differentiation of T cells and further maintain the intestinal immune homeostasis. Meanwhile, it could markedly inhibit the inflammatory signaling pathway to improve intestinal barrier function, relieving type 2 diabetes mellitus.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.

Xiexin Tang restores gut barrier function by regulating the differentiation of CD4+ T cells via GPRs and HDACs in T2DM rats.

Abstract

Xiexin Tang restores gut barrier function by regulating the differentiation of CD4⁺ T cells via GPRs and HDACs in T2DM rats.