{"title":"P1 adhesin genotype characteristics of <i>Mycoplasma pneumoniae</i> in China from 2017 to 2019.","authors":"Shirong Li, Haiwei Dou, Dawei Shi, Ruijie Yuan, Peng Tu, Qing Yuan, Deli Xin, Wenjie Qi","doi":"10.3389/fcimb.2025.1513177","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong><i>Mycoplasma pneumoniae</i> is one of the important pathogens of community-acquired pneumonia (CAP), and P1 adhesin serves as a pathogenic protein and an immune protein involved in the pathogenesis of <i>mycoplasma pneumoniae</i>. The aim of this study was to investigate the P1 adhesin genotype in <i>Mycoplasma pneumoniae</i> and its association with disease severity in patients with CAP from 2017 to 2019.</p><p><strong>Methods: </strong><i>M. pneumoniae</i> was identified in patient samples by real-time quantitative polymerase chain reaction (qPCR). The P1 genotypes of samples were determined using a culture-independent P1 typing method.</p><p><strong>Results: </strong>In total, 1,907 clinical samples were collected from 13 tertiary hospitals in Beijing, Shenyang, and Baotou, including 1488 samples from children and 419 from adults. Of these, 820 samples (43.00%), including 777 from children and 43 from adults, were positive for <i>M. pneumoniae</i>. 797 samples were successfully typed using the culture-independent P1 typing method (P1-1, 605; P1- 2, 192). The <i>M. pneumoniae</i> detection rate and P1-1 detection rate differed significantly between children and adults (both <i>p</i> < 0.01), with P1-1 remaining the dominant genotype. The proportion of P1-2 samples increased in children from 16.75% in 2017 to 28.76% in 2019.</p><p><strong>Discussion: </strong>No relationship between the P1 genotype and disease severity was identified. Monitoring the genotype changes of P1 adhesin in local populations may positively impact the epidemiological prevention and control of <i>M. pneumoniae</i> infections.</p>","PeriodicalId":12458,"journal":{"name":"Frontiers in Cellular and Infection Microbiology","volume":"15 ","pages":"1513177"},"PeriodicalIF":4.6000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872919/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cellular and Infection Microbiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fcimb.2025.1513177","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Mycoplasma pneumoniae is one of the important pathogens of community-acquired pneumonia (CAP), and P1 adhesin serves as a pathogenic protein and an immune protein involved in the pathogenesis of mycoplasma pneumoniae. The aim of this study was to investigate the P1 adhesin genotype in Mycoplasma pneumoniae and its association with disease severity in patients with CAP from 2017 to 2019.
Methods: M. pneumoniae was identified in patient samples by real-time quantitative polymerase chain reaction (qPCR). The P1 genotypes of samples were determined using a culture-independent P1 typing method.
Results: In total, 1,907 clinical samples were collected from 13 tertiary hospitals in Beijing, Shenyang, and Baotou, including 1488 samples from children and 419 from adults. Of these, 820 samples (43.00%), including 777 from children and 43 from adults, were positive for M. pneumoniae. 797 samples were successfully typed using the culture-independent P1 typing method (P1-1, 605; P1- 2, 192). The M. pneumoniae detection rate and P1-1 detection rate differed significantly between children and adults (both p < 0.01), with P1-1 remaining the dominant genotype. The proportion of P1-2 samples increased in children from 16.75% in 2017 to 28.76% in 2019.
Discussion: No relationship between the P1 genotype and disease severity was identified. Monitoring the genotype changes of P1 adhesin in local populations may positively impact the epidemiological prevention and control of M. pneumoniae infections.
期刊介绍：
Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.
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