Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, Indonesia.

IF 4.6 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI:10.3389/fcimb.2025.1504741

Inke Nadia Diniyanti Lubis, Irbah Rea Alvieda Nainggolan, Meliani Meliani, Beby Syofiani Hasibuan, Kumuthamalar Sangaran, Luqman Samsudin, Sriwipa Chuangchaiya, Paul Cliff Simon Divis, Ranti Permatasari, Zulkarnain Md Idris

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Abstract

Introduction: The incidence of malaria in Indonesia has declined significantly over the last few decades. Thus, a demand for more sensitive techniques to describe low levels of transmission in the country is important. This study was conducted to evaluate antibody response to Plasmodium falciparum and Plasmodium vivax in an area nearing elimination in North Sumatera Province, Indonesia.

Methods: A cross-sectional survey was conducted in Langkat district, North Sumatera Province, in June 2019. Basic demographic data and filter paper blood spots were collected from 339 participants. Antibody responses to two P. falciparum (PfAMA-1 and PfMSP-1₁₉) and two P. vivax (PvAMA-1 and PvMSP-1₁₉) antigens were measured using indirect enzyme-linked immunosorbent assay (ELISA). Seroconversion rates (SCR) were estimated by fitting a simple reversible catalytic model to seroprevalence data for each antibody. Multiple logistic regression was used to investigate factors associated with exposure.

Results: The overall malaria seroprevalence was 10.6% for PfAMA-1, 13% for PfMSP-1₁₉, 18.6% for PvAMA-1, and 7.4% for PvMSP-1₁₉. Seropositive individuals for P. falciparum (PfAMA-1/PfMSP-1₁₉) and P. vivax (PvAMA-1/PvMSP-1₁₉) were similar at 20.7%, with no significant differences observed between age groups (p > 0.05). Based on the reversible catalytic model, the calculated SCRs indicated a higher level of P. falciparum transmission than P. vivax using all tested antigens. In the adjusted model, only spending nights in the forest was associated with P. vivax seropositivity (odd ratio: 3.93, p < 0.001).

Conclusion: The analysis of community-based serological data helps describe the similar levels of P. falciparum and P. vivax transmission in the Langkat district. The use of a serological approach enhances the detection of past exposure, aiding in the identification of epidemiological risk factors and malaria surveillance in low transmission settings in Indonesia.

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.