Risk Factors for Incomplete Occlusion in Patients with Small Intracranial Aneurysms (<7 mm) after Flow-Diversion Treatment: A Multicenter Experience.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

Cerebrovascular Diseases Pub Date : 2025-03-03 DOI:10.1159/000544991

Chi Huang, Xingwei Lei, Xin Feng, Xin Tong, Zhuohua Wen, Jiancheng Lin, Mengshi Huang, Chao Peng, Tao Wang, Wenxin Chen, Lele Dai, Xin Jin, Shixing Su, Xin Zhang, Xifeng Li, Zongduo Guo, Aihua Liu, Chuanzhi Duan

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引用次数: 0

Abstract

Introduction: The indicator of flow diverters (FDs) received approval extension for small (<7 mm) unruptured intracranial aneurysms (UIAs). However, the factors related to aneurysm occlusion remain unclear. Thus, we conducted a multicenter analysis to explore the risk factors for incomplete occlusion (ICO) following FD implantation for small UIAs.

Methods: We retrospectively reviewed patients from 5 comprehensive hospitals in China with small UIAs treated with either Pipeline or Tubridge between September 2018 and September 2022. Baseline data were prospectively collected at admission. The relationship between baseline characteristics and occlusion status was analyzed, and multivariate logistic regression models were performed to identify the independently related factors.

Results: A total of 565 patients with 565 small UIAs were enrolled. During a mean angiographic follow-up of 10.64 ± 5.99 months, ICO was detected in 116 cases (20.5%). After adjusting for candidate variables, hypertension (adjusted odds ratio [aOR] = 2.274, 95% confidence interval [CI] = 1.462-3.538, p < 0.001), coronary disease (aOR = 2.742, 95% CI = 1.148-6.552, p = 0.023), larger aneurysm size (aOR = 1.833, 95% CI = 1.425-2.356, p < 0.001), lower size ratio (SR, aOR = 0.380, 95% CI = 0.166-0.869, p = 0.022), and less coil application (aOR = 0.212, 95% CI = 0.061-0.741, p = 0.015) were independently associated with ICO of small UIAs.

Conclusion: Hypertension, coronary disease, larger aneurysm size, lower SR, and less coil application were independent predictors of ICO for small UIAs after FD implantation. Neurointerventionalists should focus more on blood pressure management and aneurysm morphological assessment in flow-diversion treatment for small UIAs.

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.