Interleukin-6: Molecular Mechanisms and Therapeutic Perspectives in Atrial Fibrillation.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Medical Science Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI:10.1007/s11596-025-00021-7

Jin-Fang Yu, Qian Dong, Yi-Mei Du

引用次数: 0

Abstract

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with a multifactorial pathophysiology involving electrical, structural, and autonomic remodeling of the atria. AF is closely associated with elevated interleukin-6 (IL-6) levels, which contribute to atrial remodeling and the progression of AF. This review summarizes the mechanisms by which IL-6 promotes AF through inflammatory pathways, atrial fibrosis, electrical remodeling, and calcium mishandling. Experimental models have demonstrated that IL-6 neutralization reduces the incidence of AF, highlighting its potential as a therapeutic target. Future studies should focus on IL-6 blockade strategies to manage AF, aiming to improve patient outcomes.

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白细胞介素-6：心房颤动的分子机制和治疗前景。

心房颤动（AF）是一种常见的心律失常，具有多因素病理生理，涉及心房的电、结构和自主神经重塑。房颤与白细胞介素-6 （IL-6）水平升高密切相关，IL-6参与心房重构和房颤的进展。本文综述了IL-6通过炎症途径、心房纤维化、电重构和钙处理不当促进房颤的机制。实验模型表明，IL-6中和可降低房颤的发生率，突出其作为治疗靶点的潜力。未来的研究应侧重于IL-6阻断策略来管理房颤，旨在改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.70

自引率

0.00%

发文量

126

期刊介绍： Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.