Fujin Shengji Powder promotes healing of stage 3 pressure injury wounds in rats by modulating angiogenesis and inflammatory effects.

IF 2.6 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

3 Biotech Pub Date : 2025-03-01 Epub Date: 2025-02-26 DOI:10.1007/s13205-025-04237-1

Jing Gao, Dingxi Bai, Wenting Ji, Wei Wang, Xuemei Xie, Hang Li, Chaoming Hou

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Abstract

This study aimed to investigate the role of Fujin Shengji Powder (FJSJP) in promoting the healing of stage 3 pressure injury (PI) wounds and potential mechanisms. High-performance liquid chromatography was used to identify active components in FJSJP. A rat model of stage 3 PI wounds was induced via ischemia-reperfusion (I/R) injury. After successful modeling, rats in the control group received no treatment, while the positive group, negative group, and FJSJP group applied rb-bFGFG, vaseline, FJSJP to the wound, respectively, covering the wound by 2 mm continuously for 14 days. Results showed that the wound healing rate on days 3, 7, and 14 was higher in the FJSJP group than in the control groups, with complete re-epithelialization and evident regeneration of skin structures. Furthermore, FJSJP increased CD31 positive expression and elevated mRNA and protein levels of VEGF, VEGFR2, and ERK1/2 at the wound site. The anti-inflammatory effect was confirmed by reduced CD86 positive expression and downregulated TNF-α and IL-6. In summary, topical application of FJSJP can effectively treat stage 3 PI wounds in rats, providing new insights and evidence for its role in accelerating wound healing, promoting angiogenesis, and reducing inflammation.

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藤黄生肌散通过调节血管生成和炎症效应，促进大鼠第 3 期压力损伤伤口的愈合。

本研究旨在探讨扶正生筋散对3期压伤（PI）创面愈合的促进作用及其机制。采用高效液相色谱法对其有效成分进行鉴定。采用缺血再灌注（I/R）法建立大鼠3期PI损伤模型。造模成功后，对照组大鼠不给药，阳性组、阴性组、FJSJP组分别在创面涂抹rb-bFGFG、凡士林、FJSJP，连续覆盖创面2mm，持续14天。结果显示，FJSJP组创面愈合率在第3、7、14天均高于对照组，皮肤结构再生明显，上皮再生完全。此外，FJSJP增加了CD31的阳性表达，并升高了伤口部位VEGF、VEGFR2和ERK1/2的mRNA和蛋白水平。CD86阳性表达降低，TNF-α和IL-6下调，证实了抗炎作用。综上所述，FJSJP外用可有效治疗大鼠3期PI创面，为其加速创面愈合、促进血管生成、减轻炎症的作用提供了新的见解和证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

3 Biotech Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

6.00

自引率

0.00%

发文量

314

期刊介绍： 3 Biotech publishes the results of the latest research related to the study and application of biotechnology to: - Medicine and Biomedical Sciences - Agriculture - The Environment The focus on these three technology sectors recognizes that complete Biotechnology applications often require a combination of techniques. 3 Biotech not only presents the latest developments in biotechnology but also addresses the problems and benefits of integrating a variety of techniques for a particular application. 3 Biotech will appeal to scientists and engineers in both academia and industry focused on the safe and efficient application of Biotechnology to Medicine, Agriculture and the Environment.