Exploration of the role of AIM2/IL-1β in adult laryngeal papilloma.

IF 2.6 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress Pub Date : 2025-01-01 DOI:10.1177/00368504241292457

Gaofei Yin, Xiaohong Chen, Yang Zhang, Zhigang Huang, Wei Guo

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引用次数: 0

Abstract

Objectives: Human papillomavirus (HPV) infection is closely related to upper respiratory mucosal lesions, and the most common disease is adult upper respiratory papilloma, which has a certain probability of cancer transformation.This study conducted in vitro tissue and cell experiments to explore the inflammatory mechanisms associated with HPV + adult laryngeal papilloma.

Methods: We compared differential expression of AIM2 and IL-1β between HPV (High-risk) negative and positive adult laryngeal papilloma patients. In vitro experiments were conducted to investigate the differences in expression of AIM2, Caspase-1, and IL-1β in HPV- and HPV+ upper respiratory mucosal cells.

Results: The expression level of AIM2 and IL-1β was higher in HPV (High-risk) positive papilloma tissue than HPV (High-risk) negative papilloma tissue. The expression of AIM2, Caspase-1, and IL-1β in HPV+ cells was also significantly higher than in HPV- cells.

Conclusions: The expression of IL-1β mediated by AIM2 was associated with chronic inflammation of upper respiratory mucosal tissue caused by HPV infection, and it may yet be associated with further pathological changes.

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AIM2/IL-1β在成人喉乳头状瘤中的作用探讨。

目的：人乳头瘤病毒（HPV）感染与上呼吸道粘膜病变密切相关，最常见的疾病是成人上呼吸道乳头状瘤，有一定的癌变概率。本研究通过体外组织和细胞实验，探讨HPV +成人喉乳头状瘤的炎症机制。方法：比较HPV（高危）阴性和阳性成人喉乳头瘤患者AIM2和IL-1β的表达差异。通过体外实验研究了AIM2、Caspase-1和IL-1β在HPV-和HPV+上呼吸道粘膜细胞中的表达差异。结果：AIM2和IL-1β在HPV（高危）阳性乳头瘤组织中的表达水平高于HPV（高危）阴性乳头瘤组织。AIM2、Caspase-1和IL-1β在HPV+细胞中的表达也显著高于HPV-细胞。结论：AIM2介导的IL-1β表达与HPV感染引起的上呼吸道黏膜组织慢性炎症有关，并可能与进一步的病理改变有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Progress Multidisciplinary-Multidisciplinary

CiteScore

3.80

自引率

0.00%

发文量

119

期刊介绍： Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.