Recurrence of sexually transmitted infections is commonly found in a subpopulation of Austrian users of HIV pre-exposure prophylaxis.

IF 1.9 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Wiener Klinische Wochenschrift Pub Date : 2025-03-02 DOI:10.1007/s00508-025-02499-6

Nikolaus Urban, Thomas Neidhart, Katharina Grabmeier-Pfistershammer, Veronique Touzeau-Roemer, Kaspar Laurenz Schmidt, Robert Strassl, Wolfgang Weninger, Birgit Willinger, Wolfgang Michael Bauer, David Chromy

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引用次数: 0

Abstract

Background: In recent years there has been an increase in the diagnoses of sexually transmitted infections (STI) among men who have sex with men (MSM) using human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP); however, data on PrEP users in Austria are limited.

Patients, material and methods: In June 2020, we initiated a prospective observational cohort study at Vienna General Hospital including PrEP users from Vienna. Participants underwent STI testing quarterly and provided behavioral information using a questionnaire.

Results: Between June 2020 and December 2023 a total of 360 individuals (99% MSM) were enrolled comprising 379 person-years of follow-up. We identified 276 STIs in 154 individuals, of which 23% (36/154) were symptomatic. The incidence rates per 100 person-years were 29.9 (95% confidence interval, CI 24.3-35.3 per 100 person-years) for gonorrhea, 22.7 (95% CI 17.9-27.5 per 100 person-years) for chlamydia and 9.8 (95% CI 6.6-12.9 per 100 person-years) for syphilis. Extragenital infections accounted for 95% (97/102) of gonorrhea and 81% (65/80) of chlamydia cases. A case of HIV infection was recorded in a 20-year-old male with inconsistent PrEP use. Participants with one or more reinfection (18%; 65/360) accounted for 68% (187/276) of all STIs. Sexualized drug use (Chemsex) was reported by 44% (157/360) of participants and was significantly associated with higher rates of gonorrhea (38% vs. 21%, p < 0.001) and syphilis (17% vs. 5%, p < 0.001) but not chlamydia (26% vs. 19%, p = 0.118).

Conclusion: Throughout the study, 43% of participants experienced a bacterial STI, which was mostly asymptomatic and at extragenital sites. Chemsex was commonly reported and identified as a predictor for STI reinfection, underlining the importance of harm reduction strategies in Austrian STI prevention.

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性传播感染的复发在奥地利艾滋病毒暴露前预防的一个亚群中很常见。

背景：近年来，使用人类免疫缺陷病毒（HIV）暴露前预防（PrEP）在男男性行为者（MSM）中诊断出性传播感染（STI）的人数有所增加；然而，奥地利PrEP使用者的数据有限。患者、材料和方法：2020年6月，我们在维也纳总医院启动了一项前瞻性观察队列研究，包括来自维也纳的PrEP使用者。参与者每季度接受一次性传播感染检测，并通过问卷提供行为信息。结果：在2020年6月至2023年12月期间，共有360人（99%为男男性行为者）入组，包括379人年的随访。我们在154个人中发现了276个性传播感染，其中23%（36/154）有症状。淋病的发病率为每100人年29.9例（95%可信区间，CI 24.3-35.3例/ 100人年），衣原体为22.7例（95% CI 17.9-27.5例/ 100人年），梅毒为9.8例（95% CI 6.6-12.9例/ 100人年）。淋病和衣原体感染分别占95%（97/102）和81%（65/80）。1例20岁男性感染艾滋病毒，使用PrEP前后不一致。有一次或多次再感染的参与者(18%；65/360)占所有性传播感染的68%（187/276）。44%（157/360）的参与者报告了性药物使用（Chemsex），并且与淋病的高发病率显著相关（38%对21%，p ）。结论：在整个研究中，43%的参与者经历了细菌性性传播感染，其中大多数是无症状的，并且发生在生殖器外部位。Chemsex经常被报道并被确定为STI再感染的预测因子，这强调了减少危害策略在奥地利STI预防中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wiener Klinische Wochenschrift 医学-医学：内科

CiteScore

4.70

自引率

3.80%

发文量

110

审稿时长

4-8 weeks

期刊介绍： The Wiener klinische Wochenschrift - The Central European Journal of Medicine - is an international scientific medical journal covering the entire spectrum of clinical medicine and related areas such as ethics in medicine, public health and the history of medicine. In addition to original articles, the Journal features editorials and leading articles on newly emerging topics, review articles, case reports and a broad range of special articles. Experimental material will be considered for publication if it is directly relevant to clinical medicine. The number of international contributions has been steadily increasing. Consequently, the international reputation of the journal has grown in the past several years. Founded in 1888, the Wiener klinische Wochenschrift - The Central European Journal of Medicine - is certainly one of the most prestigious medical journals in the world and takes pride in having been the first publisher of landmarks in medicine.