[Development of Methods for the Early Detection of Chemical Hazard and the Prevention of Pre-disease, Focusing on Environment, Food, and Health].

IF 0.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Hideko Sone
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引用次数: 0

Abstract

Based on the perspectives of the environment, food, and health, this review reflects on previous research examining stem cells for the early detection of chemical hazards and the development of preventive health tools. The risks posed by endocrine-disrupting chemicals in the environment are investigated, including studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), phthalate esters, and bisphenol A. Building on the findings of these studies, this review identifies emerging challenges in the field of endocrine-disrupting chemical research. Moreover, this paper explores innovative testing methods aimed at accurately evaluating the impact of chemicals on human health. The key topics covered include the implementation of developmental neurotoxicity testing methods, the species-specific effects of methylmercury, nanomaterials and the application of human pluripotent cells to assess the effects of low-dose radiation. Additionally, this review highlights transformative approaches in chemical health impact assessment that integrate cell science and artificial intelligence, and addresses challenges related to the application of multi-omics technologies in environmental health and toxicology.

本综述从环境、食品和健康的角度出发,回顾了以往研究干细胞用于早期检测化学危害和开发预防性健康工具的情况。在这些研究成果的基础上,本综述指出了干扰内分泌的化学品研究领域新出现的挑战。此外,本文还探讨了旨在准确评估化学品对人类健康影响的创新测试方法。其中涉及的关键主题包括发育神经毒性测试方法的实施、甲基汞的物种特异性影响、纳米材料以及应用人类多能细胞评估低剂量辐射的影响。此外,本综述还重点介绍了整合细胞科学和人工智能的化学健康影响评估变革性方法,并探讨了环境健康和毒理学中应用多组学技术的相关挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
169
审稿时长
1 months
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