The pharmacogenomic biomarkers and clinical effect of FSHR gene variants on female infertility.

Abstract

Objective: Aim: The aims of this study are to detect the genetic polymorphisms of FSHR rs6166 (C> T) and rs6165 (C> T) gene particularly that associated with the response to FSH treatment and their effects on the pathogenesis of infertility in Iraqi women.

Patients and methods: Materials and Methods: 210 Iraqi women, aged 20 to 34, who had just been diagnosed with infertility were included in this prospective case control research, whereas the control group consisted of 50 clinically healthy women who were free of any disorders. Following the guidelines for inclusion and exclusion in the study, each of the participating women saw a gynecologist to confirm. The time frame for this From November 2021 to June 2022, the investigation was carried out.

Results: Results: The findings of this study in infertile women, clearly indicates that multiple genotypes of FSHR gene particularly (rs6166) (C>T) and (rs6165) (C>T), that include the homozygous wild genotype (CC), homozygous mutant (TT) and heterozygous (CT) genotype. The T allele was significantly increased (P<0.05) in poor responder infertile women for both rs6166 and rs6165 in FSHR which associated significantly with poor response to FSH in Iraqi infertile women.

Conclusion: Conclusions: Polymorphisms in FSHR gene may be associated with decrease in response to FSH treatment and it was associated with pathogenesis of infertility in Iraqi women/ Kerbala province.