Trunk muscle differentiation-a lesson from the Chinese fire-bellied newt (Hypselotriton orientalis).

IF 2.5 3区生物学 Q3 CELL BIOLOGY

Protoplasma Pub Date : 2025-03-01 DOI:10.1007/s00709-025-02047-z

Magda Dubińska-Magiera, Marta Julianna Brania, Krzysztof Kolenda, Katarzyna Haczkiewicz-Leśniak, Małgorzata Daczewska, Marta Migocka-Patrzałek

引用次数: 0

Abstract

Extant amphibians are divided into three distinct lineages: Gymnophiona, Urodela, and Anura. Owing to their diversity, they are widely used in research concerning, among others, tissue regeneration. Here, we describe larval myotomal myogenesis in the Chinese fire-bellied newt, Hypselotriton orientalis. Morphological, ultrastructural, cytochemical, and immunohistochemical analyses showed that trunk muscles grow through hypertrophy and hyperplasia mediated by the expression of typical myogenic factors, such as Pax7, from muscle progenitor cells. Our findings also suggest a third alternative mechanism for muscle growth involving the muscle splitting or fragmentation of preexisting larval myotubes.

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躯干肌肉的分化——来自中国火腹蝾螈（Hypselotriton orientalis）的教训。

现存的两栖动物分为三个不同的分支：裸子目、尾尾目和无尾目。由于它们的多样性，它们被广泛应用于组织再生等方面的研究。在这里，我们描述了中国火腹蝾螈（Hypselotriton orientalis）的幼虫肌瘤性肌发生。形态学、超微结构、细胞化学和免疫组织化学分析表明，躯干肌肉的生长是由肌肉祖细胞中Pax7等典型肌源性因子的表达介导的肥大和增生。我们的研究结果还提示了肌肉生长的第三种替代机制，涉及肌肉分裂或先前存在的幼虫肌管断裂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protoplasma 生物-细胞生物学

CiteScore

6.60

自引率

6.90%

发文量

审稿时长

4-8 weeks

期刊介绍： Protoplasma publishes original papers, short communications and review articles which are of interest to cell biology in all its scientific and applied aspects. We seek contributions dealing with plants and animals but also prokaryotes, protists and fungi, from the following fields: cell biology of both single and multicellular organisms molecular cytology the cell cycle membrane biology including biogenesis, dynamics, energetics and electrophysiology inter- and intracellular transport the cytoskeleton organelles experimental and quantitative ultrastructure cyto- and histochemistry Further, conceptual contributions such as new models or discoveries at the cutting edge of cell biology research will be published under the headings "New Ideas in Cell Biology".