The impact of COVID-19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness?

IF 2.2 Q3 PHYSIOLOGY

Physiological Reports Pub Date : 2025-03-01 DOI:10.14814/phy2.70216

Guilherme Dionir Back, Murilo Rezende Oliveira, Guilherme Peixoto Tinoco Arêas, Patricia Faria Camargo, Cássia da Luz Goulart, Claudio Ricardo de Oliveira, José Carlos Bonjorno Junior, Flávia Rossi Caruso Bonjourno, Ross Arena, Audrey Borghi-Silva

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Abstract

The impact of COVID-19 on cardiorespiratory fitness (CRF) is negative, increasing the likelihood of exertional symptoms such as fatigue and shortness of breath, and adversely affecting vascular function, impairing cardiovascular health. This study investigated endothelial function and its relationship with CRF in patients who have recovered COVID-19. Patients were evaluated 1 month after infection, including clinical assessment, pulmonary function, endothelial function (measured by flow-mediated dilation), and cardiopulmonary exercise testing. COVID-19 survivors exhibited reduced exercise capacity, with poor values of peak V̇O_2peak and FMD (%) according to disease severity. However, endothelial function was worse in COVID-19 patients, regardless of severity, compared to the control group. Significant associations were observed between poorer FMD (%) and peak V̇O₂, workload, circulatory power, and V̇O_2peak/WR. Endothelial function was significantly associated with CRF in COVID-19 patients according to disease severity. Strategies to improve CRF and reduce the negative impacts of endothelial function damage should be further investigated.

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COVID-19 对心肺功能（CRF）的影响是负面的，会增加出现疲劳和气短等劳累症状的可能性，并对血管功能产生不利影响，损害心血管健康。本研究调查了 COVID-19 康复患者的内皮功能及其与 CRF 的关系。患者在感染 1 个月后接受了评估，包括临床评估、肺功能、内皮功能（通过血流介导的扩张测量）和心肺运动测试。COVID-19幸存者的运动能力下降，根据疾病严重程度，其峰值V鄄O2peak和FMD（%）值较差。然而，与对照组相比，COVID-19 患者的内皮功能较差，无论严重程度如何。较差的 FMD（%）与 V̇O2 峰值、工作量、循环功率和 V̇O2peak/WR 之间存在显著关联。根据疾病严重程度，COVID-19 患者的内皮功能与 CRF 显著相关。应进一步研究改善CRF和减少内皮功能损伤负面影响的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiological Reports PHYSIOLOGY-

CiteScore

4.20

自引率

4.00%

发文量

374

审稿时长

9 weeks

期刊介绍： Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.