A case of post-outbreak acute hepatitis a in a Japanese man who have sex with men infected with RIVM-HAV16-090 strain

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-02-27 DOI:10.1016/j.jiac.2025.102673

Miho Kozuki , Satoshi Tanaka , Tatsuya Shirai , Naomi Sakon , Satoshi Harada , Ayaka Kitagawa , Kensuke Matsushima , Yutaro Abe , Nobuyasu Fukutake , Hiroko Hasegawa , Shunsuke Yamamoto , Yuko Sakakibara , Ryotaro Sakamori

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引用次数: 0

Abstract

Aim

Hepatitis A outbreaks among men who have sex with men (MSM) are a growing global concern. We present a case report of acute hepatitis A in a Japanese MSM who acquired the infection after the conclusion of a recent hepatitis A outbreak in Japan during his subsequent visit to Taiwan.

Case presentation

A 27-year-old male had experienced fever, headache, and loss of appetite over the previous eight days. After his jaundiced skin was noted during a routine health examination, he visited our outpatient department that same day. The severe liver dysfunction detected in blood tests necessitated hospitalization for acute hepatitis. Subsequent tests revealed positive HA-IgM antibodies, confirming acute hepatitis A. Further inquiry revealed the patient's MSM status and recent sexual encounter one and a half months earlier during a visit to Taiwan. With conservative treatment, his condition improved and he was discharged after 12 days. Phylogenetic analysis extracted from his stool sample confirmed that the hepatitis A virus (HAV) strain was RIVM-HAV16-090, consistent with strains observed in previous hepatitis outbreaks among MSM populations.

Conclusion

To the best of our knowledge, this is the first case report of acute hepatitis A in a Japanese MSM sporadically infected with the RIVM-HAV16-090 strain since the end of the outbreak. This case underscores the persistent risk of hepatitis A transmission among MSM despite the cessation of the outbreak, emphasizing the importance of targeted vaccination campaigns, sexual health education, and ongoing vigilance in mitigating the risk of hepatitis A transmission among MSM.

查看原文本刊更多论文

一例日本男性同性性行为者感染 RIVM-HAV16-090 株病毒后爆发急性甲型肝炎的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.