A case of post-outbreak acute hepatitis a in a Japanese man who have sex with men infected with RIVM-HAV16-090 strain

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-02-27 DOI:10.1016/j.jiac.2025.102673

Miho Kozuki , Satoshi Tanaka , Tatsuya Shirai , Naomi Sakon , Satoshi Harada , Ayaka Kitagawa , Kensuke Matsushima , Yutaro Abe , Nobuyasu Fukutake , Hiroko Hasegawa , Shunsuke Yamamoto , Yuko Sakakibara , Ryotaro Sakamori

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引用次数: 0

Abstract

Aim

Hepatitis A outbreaks among men who have sex with men (MSM) are a growing global concern. We present a case report of acute hepatitis A in a Japanese MSM who acquired the infection after the conclusion of a recent hepatitis A outbreak in Japan during his subsequent visit to Taiwan.

Case presentation

A 27-year-old male had experienced fever, headache, and loss of appetite over the previous eight days. After his jaundiced skin was noted during a routine health examination, he visited our outpatient department that same day. The severe liver dysfunction detected in blood tests necessitated hospitalization for acute hepatitis. Subsequent tests revealed positive HA-IgM antibodies, confirming acute hepatitis A. Further inquiry revealed the patient's MSM status and recent sexual encounter one and a half months earlier during a visit to Taiwan. With conservative treatment, his condition improved and he was discharged after 12 days. Phylogenetic analysis extracted from his stool sample confirmed that the hepatitis A virus (HAV) strain was RIVM-HAV16-090, consistent with strains observed in previous hepatitis outbreaks among MSM populations.

Conclusion

To the best of our knowledge, this is the first case report of acute hepatitis A in a Japanese MSM sporadically infected with the RIVM-HAV16-090 strain since the end of the outbreak. This case underscores the persistent risk of hepatitis A transmission among MSM despite the cessation of the outbreak, emphasizing the importance of targeted vaccination campaigns, sexual health education, and ongoing vigilance in mitigating the risk of hepatitis A transmission among MSM.

查看原文本刊更多论文

一例日本男性同性性行为者感染 RIVM-HAV16-090 株病毒后爆发急性甲型肝炎的病例。

目的：在男男性行为者（MSM）中爆发甲型肝炎是一个日益受到全球关注的问题。我们提出一个病例报告急性甲型肝炎在日本男男性接触者谁获得感染后，最近的甲型肝炎爆发在日本的结论，在他随后访问台湾。病例介绍：一名27岁男性，在过去8天内出现发烧、头痛和食欲不振。在例行健康检查中发现皮肤黄疸后，他于当天来到我们的门诊部。在血液检查中发现严重的肝功能障碍，需要住院治疗急性肝炎。随后的检测显示HA-IgM抗体阳性，确认为急性甲型肝炎。进一步的调查显示患者是男男性行为者，并在一个半月前访问台湾期间有过性行为。经保守治疗，病情好转，12天后出院。从他的粪便样本中提取的系统发育分析证实，甲型肝炎病毒（HAV）毒株为RIVM-HAV16-090，与以前在男男性接触者人群中观察到的肝炎疫情毒株一致。结论：据我们所知，这是自疫情结束以来日本男男性接触者零星感染RIVM_HAV16_090毒株的首例急性甲型肝炎病例报告。这一病例强调了尽管疫情停止，但男男性行为者之间甲型肝炎传播的持续风险，强调了有针对性的疫苗接种运动、性健康教育和持续警惕以减轻男男性行为者之间甲型肝炎传播风险的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.