Cross-talk between signal transduction systems and metabolic networks in bacterial antibiotics resistance and tolerance

Abstract

The comprehensive antibiotic resistance of pathogens signifies the oneset of the “post-antibiotic era”, and the myriad treatment challenges posed by “superbugs” have emerged as the primary threat to human health. Recent studies indicate that bacterial resistance and tolerance development are mediated at the metabolic level by various signalling networks (e.g., quorum sensing systems, second messenger systems, and two-component systems), resulting in metabolic rearrangements and alterations in bacterial community behaviour. This review focuses on current research, highlighting the intrinsic link between signalling and metabolic networks in bacterial resistance and tolerance.