Discrepancy between clinical and radiological responses in non-infectious pneumonia during immunotherapy: a case report.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2025-02-01 DOI:10.26355/eurrev_202502_37100

A Pezzuto, A Ricci, T Palermo, C Salvucci, G Pelosi, F Stirpe, A Gallippi, I Pace, E Chichi, E Carico

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引用次数: 0

Abstract

Background: Immunotherapy is a widely used and effective therapy for lung malignancy. However, its acting on the immune system can cause several adverse effects.

Case report: This is a case of a 74-year-old male who was admitted to the department of pulmonology due to bilateral pneumonia. The patient was treated with maintenance immunotherapy, pembrolizumab for a stage IV lung adenocarcinoma. Concomitant clinical manifestations were pleural effusion and respiratory failure, and the main comorbidities were hypertension and atrial fibrillation. The inflammatory indices, such as C-reactive protein and procalcitonin, were slightly altered, in contrast to a severely compromised clinical-radiological picture. Blood gas analysis test reported values indicative of altered gas exchange. T lymphocytopenia was found without an evident isolate of a bacterial agent. High-dose steroid treatment was initiated, and antibiotics such as cephalosporins have been administered.

Conclusions: The patient reported a good clinical response due to a poorly modified radiological picture.

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)