Empirical Model of Focused Ultrasound-Mediated Treatment for Chemotherapy Delivery to Brain Tumors

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-03-02 DOI:10.1016/j.ultrasmedbio.2025.01.018

Mohammad Zoofaghari , Martin Damrath , Mladen Veletić , Ilangko Balasingham

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引用次数: 0

Abstract

Focused ultrasound (FUS) has emerged as a transformative technique for enhancing drug delivery to brain tumors by temporarily and locally disrupting the blood-brain barrier (BBB). Despite significant progress in both pre-clinical and clinical research, a major challenge remains: the absence of a model that connects the properties of drug particles and FUS sonication parameters to therapeutic effectiveness. In this study, we introduce a novel empirical model that integrates key factors, including drug pharmacodynamics, microbubble kinetics for BBB disruption, intrabrain ultrasound signal propagation, and skull-thickness variations. The model defines a new sonication parameter that encapsulates ultrasound signal characteristics and predicts the concentration of therapeutic agents internalized or bound to DNA with an accuracy exceeding 82%. By employing data from previous pre-clinical studies, this model facilitates the development of precise sonication protocols tailored for clinical applications. These advancements represent a significant step toward personalized FUS-mediated treatments, bridging the gap between experimental research and patient-centered therapies.

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聚焦超声介导治疗脑肿瘤化疗的经验模型。

聚焦超声（FUS）已成为一种变革性技术，通过暂时和局部破坏血脑屏障（BBB）来增强对脑肿瘤的药物输送。尽管临床前和临床研究都取得了重大进展，但仍然存在一个主要挑战：缺乏将药物颗粒特性和FUS超声参数与治疗效果联系起来的模型。在这项研究中，我们引入了一个新的经验模型，该模型集成了关键因素，包括药物药理学，血脑屏障破坏的微泡动力学，脑内超声信号传播和颅骨厚度变化。该模型定义了一个新的超声参数，封装超声信号特征，预测内化或结合DNA的治疗剂浓度，准确率超过82%。通过使用以前临床前研究的数据，该模型促进了为临床应用量身定制的精确超声方案的开发。这些进展代表了个性化fus介导治疗的重要一步，弥合了实验研究和以患者为中心的治疗之间的差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.