Association of program cell death ligand-1 (rs4143815 G>C) with some clinical symptoms and oral ulcer types in systemic lupus erythematosus.

Abstract

Objective: Aim: The study aims to detect Association of Program Cell Death Ligand-1(PD-L1) rs4143815 G>C with some Clinical Symptoms and Oral Ulcer Types in Systemic Lupus Erythematosus (SLE).

Patients and methods: Materials and Methods: A case control design was suggested in the study enrolled about 60 SLE patients and 20 healthy individuals as a control group, PD-L1 variation implemented using allele specific PCR.

Results: Results: The findings showed significant changes in age (<0.011), sex (p<0.000), and non-sig in BMI (p<0.654). in SLE group about 23.3% of patients have a family history, 93.7% suffered from fever, 51.66% have a Butterfly-shaped rash, 73.3% suffered from oral ulcer, single oral ulcer was observed 65.90% and multiple ulcer observed 34.09%. Oral mouth was more frequent (55%) while pharynx ulcer was low frequent (3.3%). The rs4143815 G>C showed three genotypes (GC, CC and GG), Significant association of CC with SLE patients (OR 67.8874, p <0.003), A non-sig association was observed in GG with SLE (OR 5.8571, p <0.395), significant association of C allele with SLE group (OR 1.3529, p< 0.0008). The PD-L1 rs4143815 (G>C) genotyping distribution according to some clinical symptoms showed a non-significant association with all symptoms. The PD-L1 rs4143815 (G>C) genotyping distribution according to oral ulcer sites showed a non-significant association also.

Conclusion: Conclusions: The present results concluded closed correlation between rs4143815 G>C and SLE patients, but no association was observed with some clinical symptoms and oral ulcer types.