Physiological roles of ghrelin in the regulation of gastrointestinal motility in vertebrates

IF 1.7 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

General and comparative endocrinology Pub Date : 2025-02-28 DOI:10.1016/j.ygcen.2025.114698

Shuangyi Zhang , Hiroyuki Kaiya , Takio Kitazawa

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引用次数: 0

Abstract

Ghrelin is known to be a multifunctional peptide hormone that stimulates not only growth hormone secretion and feeding but also gastrointestinal (GI) functions, including motility, secretion and mucosa proliferation. The aim of this review is to provide a comprehensive overview on the physiological roles of ghrelin in the regulation of GI motility from a comparative perspective. The effects of ghrelin on GI motility differ depending on the species, and ghrelin is a possible regulator of gastric migrating motor complexes (MMCs) in rodents, dogs and house musk shrew (suncus). However, the role of ghrelin has not been clarified in detail in other mammals, including humans and rabbits. Ghrelin is also effective to cause contraction in the GI tract of some non-mammals, but its physiological role is also not clarified at present. Distribution of the growth hormone secretagogue receptor (GHSR, ghrelin receptor) in the GI tract might be connected with the regulatory role of ghrelin in vertebrates. Comparative studies of ghrelin among animals and identification of knowledge gaps must lead us to the functional transition and importance of ghrelin in the GI tract.

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胃饥饿素在脊椎动物胃肠运动调节中的生理作用。

Ghrelin是一种多功能肽激素，不仅刺激生长激素的分泌和摄食，还刺激胃肠（GI）功能，包括运动、分泌和粘膜增殖。本文旨在从比较的角度对胃饥饿素在胃肠道运动调节中的生理作用进行综述。胃饥饿素对胃肠运动的影响因物种而异，胃饥饿素可能是啮齿动物、狗和麝香鼩（suncus）胃运动迁移复合体（MMCs）的调节剂。然而，胃饥饿素在包括人类和兔子在内的其他哺乳动物中的作用尚未得到详细阐明。Ghrelin在一些非哺乳动物中也能引起胃肠道收缩，但其生理作用目前也不清楚。生长激素促分泌受体（GHSR, ghrelin receptor）在脊椎动物胃肠道中的分布可能与ghrelin的调节作用有关。动物间胃饥饿素的比较研究和知识空白的识别必须使我们了解胃饥饿素在胃肠道中的功能转变和重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

General and comparative endocrinology 医学-内分泌学与代谢

CiteScore

5.60

自引率

7.40%

发文量

120

审稿时长

2 months

期刊介绍： General and Comparative Endocrinology publishes articles concerned with the many complexities of vertebrate and invertebrate endocrine systems at the sub-molecular, molecular, cellular and organismal levels of analysis.