Race- and Sex-Specific Age at Which Coronary Artery Calcium Becomes Detectable Among Young Adults.

IF 6.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Circulation: Cardiovascular Imaging Pub Date : 2025-03-01 Epub Date: 2025-03-03 DOI:10.1161/CIRCIMAGING.124.016599
Yvette A Yeboah-Kordieh, Ellen Boakye, Albert D Osei, Omar Dzaye, Zeina A Dardari, Joao A C Lima, Alan Rozanski, Daniel S Berman, Matthew J Budoff, Michael D Miedema, Khurram Nasir, John A Rumberger, Leslee J Shaw, David R Jacobs, Michael J Blaha
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引用次数: 0

Abstract

Background: Coronary artery calcium (CAC) is an excellent predictor of atherosclerotic cardiovascular disease (ASCVD) risk. Limited data exist on the age at which CAC transitions to nonzero among young adults. We aimed to assess the prevalence of CAC by the number of ASCVD risk factors and use this data to model the race- and sex-specific ages at which young adults transition to a CAC >0.

Methods: We included 17 285 participants aged 30 to 50 years from the CAC Consortium and the CARDIA (Coronary Artery Risk Development in Young Adults) study in this cross-sectional study. We estimated the burden of CAC by the number of ASCVD risk factors and used sex- and race-specific multivariable logistic regression models to predict the probability of CAC >0. From these, we estimated the age at CAC conversion from zero, using a minimum testing yield of 25%.

Results: Of the 17 285 participants included in this study (mean age, 43.3±4.7years, 66.9% men, and 87.5% White), 30.1% had CAC >0. The probability of CAC >0 at each specified age and risk factor profile was higher among men than women and White compared with Black individuals. With 2 ASCVD risk factors, the estimated age at which CAC became detectable was 36.1 (35.1-36.9) years for White men, 41.9 (40.6-43.2) years for Black men, 47.6 (46.3-48.9) years for White women, and 51.6 (48.2-54.5) years for Black women.

Conclusions: The age at which CAC becomes detectable in young adults varies substantially by race, sex, and the number of ASCVD risk factors. Earlier initiation of CAC scans may be indicated in select subgroups at greater risk of premature atherosclerosis.

在年轻人中冠状动脉钙检测的种族和性别特异性年龄。
背景:冠状动脉钙(CAC)是动脉粥样硬化性心血管疾病(ASCVD)风险的一个很好的预测指标。关于年轻人中CAC转变为非零的年龄的数据有限。我们的目的是通过ASCVD危险因素的数量来评估CAC的患病率,并使用这些数据来模拟年轻人过渡到CAC bb00的种族和性别特异性年龄。方法:我们在这项横断面研究中纳入了来自CAC联盟和CARDIA(年轻人冠状动脉风险发展)研究的17285名年龄在30至50岁之间的参与者。我们通过ASCVD危险因素的数量来估计CAC的负担,并使用性别和种族特异性多变量logistic回归模型来预测CAC的概率。从这些数据中,我们使用25%的最小测试收率,从零估计了CAC转换的年龄。结果:在本研究纳入的17285名参与者中(平均年龄43.3±4.7岁,男性占66.9%,白人占87.5%),30.1%患有CAC。在每个特定年龄和危险因素中,男性患CAC的概率高于女性,白人高于黑人。有2个ASCVD危险因素,白人男性CAC检出的估计年龄为36.1(35.1-36.9)岁,黑人男性为41.9(40.6-43.2)岁,白人女性为47.6(46.3-48.9)岁,黑人女性为51.6(48.2-54.5)岁。结论:在年轻人中检测到CAC的年龄因种族、性别和ASCVD危险因素的数量而有很大差异。在早期动脉粥样硬化风险较高的特定亚组中,可能需要更早地进行CAC扫描。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.30
自引率
2.70%
发文量
225
审稿时长
6-12 weeks
期刊介绍: Circulation: Cardiovascular Imaging, an American Heart Association journal, publishes high-quality, patient-centric articles focusing on observational studies, clinical trials, and advances in applied (translational) research. The journal features innovative, multimodality approaches to the diagnosis and risk stratification of cardiovascular disease. Modalities covered include echocardiography, cardiac computed tomography, cardiac magnetic resonance imaging and spectroscopy, magnetic resonance angiography, cardiac positron emission tomography, noninvasive assessment of vascular and endothelial function, radionuclide imaging, molecular imaging, and others. Article types considered by Circulation: Cardiovascular Imaging include Original Research, Research Letters, Advances in Cardiovascular Imaging, Clinical Implications of Molecular Imaging Research, How to Use Imaging, Translating Novel Imaging Technologies into Clinical Applications, and Cardiovascular Images.
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