The association between sedentary lifestyle and the prevalence of sarcopenia with the mediation role of systematic inflammation index, 25-hydroxyvitamin D, and testosterone: A nationwide cross-sectional study

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-02-27 DOI:10.1016/j.clnesp.2025.02.022

Jiayi Huang , Qian Li , Yifan Dou, Jiaping Li, Luyao Liu, Yiqing Xu, Na Yang, Zhaoqiang Jiang

{"title":"The association between sedentary lifestyle and the prevalence of sarcopenia with the mediation role of systematic inflammation index, 25-hydroxyvitamin D, and testosterone: A nationwide cross-sectional study","authors":"Jiayi Huang , Qian Li , Yifan Dou, Jiaping Li, Luyao Liu, Yiqing Xu, Na Yang, Zhaoqiang Jiang","doi":"10.1016/j.clnesp.2025.02.022","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>While there is some evidence of the association between sedentary behavior and sarcopenia risk, it remains unclear whether systematic inflammation index (SII), 25(OH)D, and testosterone can mediate this association. This study aims to investigate whether sedentary behavior is associated with the prevalence of sarcopenia in the US population and further examine its potential mediators which have not been thoroughly explored, thereby presenting a novel approach to understanding the mechanism between sedentary behavior and sarcopenia.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study involving a representative sample of the US national population of 9902 adults aged 18 years or older from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. The participants with sarcopenia were identified by Dual-energy X-ray (DXA) absorptiometry. Weighted multivariable logistic regressions based on the complex survey designs were used to explore the associations between a sedentary lifestyle and the risk of sarcopenia and restricted cubic spline (RCS) regression was used to examine the non-linear association. Causal mediation analysis using the quasi-Bayesian Monte Carlo method was applied to identify the mediating role of SII, 25(OH)D, and testosterone as potential mediators.</div></div><div><h3>Results</h3><div>A total of 358 participants (3.6 %) had sarcopenia. Compared to those in the lowest quartile of sedentary time, participants in the highest quartile had a hazard ratio of 1.631 (95 % CI: 1.162 to 2.289) for the prevalence of sarcopenia. A non-linear relationship (P for non-linearity <0.001) between sedentary time and the risk of sarcopenia was observed using the RCS method. The odds ratio for sarcopenia was highest (OR = 3.427) when the sedentary time was 1080 min daily. Furthermore, SII, 25(OH)D, and testosterone showed a significant mediation in the association between sedentary time and sarcopenia risk, with a mediation effect of 3.39 %, 10.3 %, and 8.56 %, respectively.</div></div><div><h3>Conclusions</h3><div>This study demonstrated novel findings of the association between sedentary behavior and sarcopenia in the US population. Our study found that sedentary time was associated with the prevalence of sarcopenia. Vitamin D, SII, and testosterone served as mediating factors in the association of sedentary time with the risk of sarcopenia.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 530-538"},"PeriodicalIF":2.9000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition ESPEN","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405457725000853","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

While there is some evidence of the association between sedentary behavior and sarcopenia risk, it remains unclear whether systematic inflammation index (SII), 25(OH)D, and testosterone can mediate this association. This study aims to investigate whether sedentary behavior is associated with the prevalence of sarcopenia in the US population and further examine its potential mediators which have not been thoroughly explored, thereby presenting a novel approach to understanding the mechanism between sedentary behavior and sarcopenia.

Methods

We conducted a cross-sectional study involving a representative sample of the US national population of 9902 adults aged 18 years or older from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. The participants with sarcopenia were identified by Dual-energy X-ray (DXA) absorptiometry. Weighted multivariable logistic regressions based on the complex survey designs were used to explore the associations between a sedentary lifestyle and the risk of sarcopenia and restricted cubic spline (RCS) regression was used to examine the non-linear association. Causal mediation analysis using the quasi-Bayesian Monte Carlo method was applied to identify the mediating role of SII, 25(OH)D, and testosterone as potential mediators.

Results

A total of 358 participants (3.6 %) had sarcopenia. Compared to those in the lowest quartile of sedentary time, participants in the highest quartile had a hazard ratio of 1.631 (95 % CI: 1.162 to 2.289) for the prevalence of sarcopenia. A non-linear relationship (P for non-linearity <0.001) between sedentary time and the risk of sarcopenia was observed using the RCS method. The odds ratio for sarcopenia was highest (OR = 3.427) when the sedentary time was 1080 min daily. Furthermore, SII, 25(OH)D, and testosterone showed a significant mediation in the association between sedentary time and sarcopenia risk, with a mediation effect of 3.39 %, 10.3 %, and 8.56 %, respectively.

Conclusions

This study demonstrated novel findings of the association between sedentary behavior and sarcopenia in the US population. Our study found that sedentary time was associated with the prevalence of sarcopenia. Vitamin D, SII, and testosterone served as mediating factors in the association of sedentary time with the risk of sarcopenia.

查看原文本刊更多论文

背景：虽然有证据表明久坐行为与肌肉疏松症风险之间存在关联，但系统性炎症指数（SII）、25（OH）D和睾酮是否能调节这种关联仍不清楚。本研究旨在调查久坐行为是否与美国人群中肌肉疏松症的患病率有关，并进一步研究其尚未被深入探讨的潜在中介因素，从而为了解久坐行为与肌肉疏松症之间的机制提供一种新方法：我们进行了一项横断面研究，研究对象是2011-2018年美国全国健康与营养调查（NHANES）中具有代表性的9902名18岁及以上成年人。研究人员通过双能 X 光（DXA）吸收测定法确定了患有肌肉疏松症的参与者。基于复杂调查设计的加权多变量逻辑回归用于探究久坐的生活方式与肌少症风险之间的关联，受限立方样条（RCS）回归用于检验非线性关联。采用准贝叶斯蒙特卡洛法进行因果中介分析，以确定 SII、25(OH)D 和睾酮的潜在中介作用：共有 358 名参与者（3.6%）患有肌肉疏松症。与久坐时间最少的四分位数参与者相比，久坐时间最多的四分位数参与者患肌肉疏松症的危险比为 1.631（95% CI：1.162 至 2.289）。使用 RCS 方法观察到久坐时间与肌肉疏松症风险之间存在非线性关系（非线性 P < 0.001）。当每天久坐时间为 1,080 分钟时，患肌肉疏松症的几率比最高（OR = 3.427）。此外，SII、25（OH）D和睾酮对久坐时间与肌肉疏松症风险之间的关联有显著的中介作用，中介效应分别为3.39%、10.3%和8.56%：本研究对美国人群的久坐行为与肌肉疏松症之间的关系进行了新的发现。我们的研究发现，久坐时间与肌肉疏松症的发病率有关。维生素 D、SII 和睾酮是久坐时间与肌肉疏松症风险之间关系的中介因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.