Youngjune Kim, Sejoon Lee, Eugene Lee, Joon Woo Lee
{"title":"Opportunistic screening of osteoporosis using CT urography: comparison of diagnostic performance between contrast phases.","authors":"Youngjune Kim, Sejoon Lee, Eugene Lee, Joon Woo Lee","doi":"10.1177/02841851251322928","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Opportunistic screening of osteoporosis using computed tomography (CT) should be optimized according to CT protocols. However, to date, no study has evaluated the different contrast phases of CT urography in osteoporosis screening.</p><p><strong>Purpose: </strong>To compare the diagnostic performance of different contrast phases of CT urography in opportunistic screening of osteoporosis.</p><p><strong>Material and methods: </strong>In this single-center retrospective study, 210 consecutive patients (181 men, 29 women; mean age = 72.0 ± 9.5 years) who underwent both CT urography and dual-energy X-ray absorptiometry (DXA) within 3 months in July to December 2020 were included. The attenuation value was measured at the center of the L1 vertebral body in the axial plane of the precontrast, corticomedullary, and excretory phases. The mean and standard deviation (SD) of attenuation values were calculated. The area under the receiver operating characteristic curve (AUC) in differentiating osteoporosis versus osteopenia/normal was measured in each phase, and non-parametric comparisons between precontrast and the other phases were performed.</p><p><strong>Results: </strong>According to DXA results, 90, 90, and 30 patients were classified into the normal, osteopenia, and osteoporosis groups, respectively. The mean ± SD of attenuation values in the precontrast, corticomedullary, and excretory phases were 114.9 ± 47.8, 132.8 ± 49.3, and 126.2 ± 47.2 HU, respectively. A significant difference was observed between AUCs measured in the precontrast (0.804, 95% confidence interval [CI] = 0.717-0.890) and corticomedullary phases (0.760, 95% CI = 0.661-0.860) (<i>P </i>= 0.003) and those between the precontrast and excretory phases (0.774, 95% CI = 0.678-0.869) (<i>P </i>= 0.005).</p><p><strong>Conclusion: </strong>The precontrast phase outperformed the other phases in the opportunistic screening of osteoporosis using CT urography.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851251322928"},"PeriodicalIF":1.1000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02841851251322928","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Opportunistic screening of osteoporosis using computed tomography (CT) should be optimized according to CT protocols. However, to date, no study has evaluated the different contrast phases of CT urography in osteoporosis screening.
Purpose: To compare the diagnostic performance of different contrast phases of CT urography in opportunistic screening of osteoporosis.
Material and methods: In this single-center retrospective study, 210 consecutive patients (181 men, 29 women; mean age = 72.0 ± 9.5 years) who underwent both CT urography and dual-energy X-ray absorptiometry (DXA) within 3 months in July to December 2020 were included. The attenuation value was measured at the center of the L1 vertebral body in the axial plane of the precontrast, corticomedullary, and excretory phases. The mean and standard deviation (SD) of attenuation values were calculated. The area under the receiver operating characteristic curve (AUC) in differentiating osteoporosis versus osteopenia/normal was measured in each phase, and non-parametric comparisons between precontrast and the other phases were performed.
Results: According to DXA results, 90, 90, and 30 patients were classified into the normal, osteopenia, and osteoporosis groups, respectively. The mean ± SD of attenuation values in the precontrast, corticomedullary, and excretory phases were 114.9 ± 47.8, 132.8 ± 49.3, and 126.2 ± 47.2 HU, respectively. A significant difference was observed between AUCs measured in the precontrast (0.804, 95% confidence interval [CI] = 0.717-0.890) and corticomedullary phases (0.760, 95% CI = 0.661-0.860) (P = 0.003) and those between the precontrast and excretory phases (0.774, 95% CI = 0.678-0.869) (P = 0.005).
Conclusion: The precontrast phase outperformed the other phases in the opportunistic screening of osteoporosis using CT urography.
期刊介绍:
Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.