Sieging tumor cells using an amorphous ferric coordination polymer.

IF 12.2 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Materials Horizons Pub Date : 2025-03-03 DOI:10.1039/d4mh01558d

Yanli Li, Ruoqi Zhang, Yuanye Dang, Yongyu Liang, Lulu Wang, Na Chen, Luwen Zhuang, Wen Liu, Teng Gong

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Abstract

Metastasis is one of the main reasons for cancer treatment failure. Unfortunately, most treatment approaches inevitably damage the extracellular matrix (ECM) during tumor cell elimination, thereby augmenting the risk of metastasis. Herein, we proposed a "sieging tumor cells" strategy based on ferric coordination polymers (FeCPs), which involved anchoring tumor cells through ECM consolidation and selectively eliminating them in the tumor regions. Due to the weak coordination interactions and amorphous structure of FeCPs, the acidic tumor microenvironment facilitated their disintegration, releasing salicylic acid (SA), 2,5-dihydroxyterephthalic acid (DHTA) and Fe³⁺ ions. The released SA inhibited heparinase activity to consolidate the ECM, while Fe-mediated chemodynamic therapy (CDT) was enhanced by DHTA due to its fast electron transport behavior, ultimately inhibiting tumor growth and metastasis. The results from the orthotopic 4T1 breast tumor model indicated that lung metastasis was reduced by about 90%, and the survival rate improved by 70% after FeCP treatment. Overall, this "sieging tumor cells" strategy provides an emerging approach for the treatment of malignant tumors by consolidating the ECM in combination with self-enhanced CDT.

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使用无定形铁配位聚合物包围肿瘤细胞。

转移是癌症治疗失败的主要原因之一。遗憾的是，大多数治疗方法在消灭肿瘤细胞的过程中不可避免地会破坏细胞外基质（ECM），从而增加转移的风险。在此，我们提出了一种基于铁配位聚合物（FeCPs）的 "围攻肿瘤细胞 "策略，即通过ECM固化锚定肿瘤细胞，并在肿瘤区域选择性地消灭它们。由于铁配位聚合物的弱配位相互作用和无定形结构，酸性肿瘤微环境促进了它们的分解，释放出水杨酸（SA）、2,5-二羟基对苯二甲酸（DHTA）和Fe3+离子。释放出的水杨酸可抑制肝素酶的活性，从而巩固 ECM，而 DHTA 的快速电子传递行为可增强铁介导的化学动力疗法（CDT），最终抑制肿瘤的生长和转移。正位 4T1 乳腺肿瘤模型的研究结果表明，FeCP 治疗后，肺转移减少了约 90%，生存率提高了 70%。总之，这种 "围攻肿瘤细胞 "的策略为通过巩固 ECM 并结合自增强 CDT 治疗恶性肿瘤提供了一种新方法。

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来源期刊

Materials Horizons CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

18.90

自引率

2.30%

发文量

306

审稿时长

1.3 months

期刊介绍： Materials Horizons is a leading journal in materials science that focuses on publishing exceptionally high-quality and innovative research. The journal prioritizes original research that introduces new concepts or ways of thinking, rather than solely reporting technological advancements. However, groundbreaking articles featuring record-breaking material performance may also be published. To be considered for publication, the work must be of significant interest to our community-spanning readership. Starting from 2021, all articles published in Materials Horizons will be indexed in MEDLINE©. The journal publishes various types of articles, including Communications, Reviews, Opinion pieces, Focus articles, and Comments. It serves as a core journal for researchers from academia, government, and industry across all areas of materials research. Materials Horizons is a Transformative Journal and compliant with Plan S. It has an impact factor of 13.3 and is indexed in MEDLINE.