Zebrafish embryo toxicity to ssDNA-wrapped carbon nanotube dispersion: From whole-body to single-cell resolution

IF 10.5 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Carbon Pub Date : 2025-02-24 DOI:10.1016/j.carbon.2025.120127

Hyeon Mi Sung , Eun Jung Kwon , Dakyeon Lee , Yunseo Jung , Yun Hak Kim , Chang-Kyu Oh , Sanghwa Jeong

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引用次数: 0

Abstract

Single-walled carbon nanotubes (SWCNTs) possess exceptional mechanical, electrical, and chemical properties, making them highly valuable for applications across various fields. However, concerns about their potential toxicity, particularly in biological contexts, have limited their broader use. In this study, we evaluated the biocompatibility of (GT)₆ ssDNA-wrapped SWCNTs using zebrafish embryos as a model organism. Zebrafish embryos were exposed to SWCNT concentrations of 2 mg/L and 10 mg/L, and their development was monitored over 96 h post-fertilization. We observed no significant differences in survival, growth, heart rate, and hatching rates between ssDNA-coated SWCNTs exposed embryos and controls. Additionally, single-cell RNA sequencing revealed no significant changes in gene expression across multiple cell types, further supporting the biocompatibility of ssDNA-coated SWCNTs. This research contributes to the growing body of knowledge regarding SWCNT safety and supports their potential for wider applications in drug delivery, biosensing, and other advanced material fields.

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斑马鱼胚胎对ssDNA包裹的碳纳米管分散体的毒性：从全身到单细胞分辨率

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来源期刊

Carbon 工程技术-材料科学：综合

CiteScore

20.80

自引率

7.30%

发文量

审稿时长

23 days

期刊介绍： The journal Carbon is an international multidisciplinary forum for communicating scientific advances in the field of carbon materials. It reports new findings related to the formation, structure, properties, behaviors, and technological applications of carbons. Carbons are a broad class of ordered or disordered solid phases composed primarily of elemental carbon, including but not limited to carbon black, carbon fibers and filaments, carbon nanotubes, diamond and diamond-like carbon, fullerenes, glassy carbon, graphite, graphene, graphene-oxide, porous carbons, pyrolytic carbon, and other sp2 and non-sp2 hybridized carbon systems. Carbon is the companion title to the open access journal Carbon Trends. Relevant application areas for carbon materials include biology and medicine, catalysis, electronic, optoelectronic, spintronic, high-frequency, and photonic devices, energy storage and conversion systems, environmental applications and water treatment, smart materials and systems, and structural and thermal applications.