Synthesis of benzofuro[3,2-c]quinolinones via one-pot reaction of 3-chlorooxindoles and salicylaldehydes

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-02-27 DOI:10.1016/j.tet.2025.134568

Feng Wang , Sheng-Bin Wang , Jia-Qi Pan , Qiu-Yu Ma , Mingshu Wu , Rui Ning

引用次数: 0

Abstract

A mild and efficient one-pot reaction for constructing benzofuro[3,2-c]quinolinones from 3-chlorooxindoles and salicylaldehydes is presented. The method involves the base-mediated formation of a dihydrobenzofuran spirooxindole intermediate, which is subsequently converted into benzofuro[3,2-c]quinolinones facilitated by TfOH. This strategy is characterized by transition metal-free conditions, easily accessible starting materials, and a broad substrate scope.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.