Impact of reconstruction algorithms at different sphere-to-background ratios on PET quantification: A phantom study

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-02-27 DOI:10.1016/j.apradiso.2025.111761

Ahmed A. Mohymen , Hamed I. Farag , Sameh M. Reda , Ahmed S. Monem , Said A. Ali

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引用次数: 0

Abstract

Using National Electrical Manufacturers Association (NEMA) phantom, the behavior of four distinct Positron Emission Tomography/Computed Tomography (PET/CT) reconstruction algorithms was investigated. These reconstruction algorithms were (Ordered Subset Expectation Maximization (OSEM), OSEM+ (Point Spread Function) PSF, OSEM + Time of Flight (TOF), and OSEM + TOF + PSF), and the focus was on sphere sizes and SBRs using recovery coefficients as a quantitation method. The obtained results demonstrated the significant effect of TOF on Gibbs artifact and Partial Volume Effect (PVE) at various Sphere-to-Background Ratios (SBRs). TOF-based algorithms improved quantification accuracy and mitigated the influence of Gibbs artifact, particularly at higher SBRs. Compared to PSF algorithm, TOF- based algorithms effectively mitigated the impact of PVE on small-sized spheres and less dependent on SBRs. In terms of Standardized Uptake Value (SUV) quantification, SUVmean was better when utilizing TOF-based algorithms at lower SBRs, whereas SUVmax at higher SBRs. The combination of TOF and PSF produced a promising outcomes in quantifying and detecting a small-sized spheres across various SBRs, ultimately resulting in a more reliable and precise diagnostic information.

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不同球背景比下重建算法对PET定量的影响：一项模拟研究

利用美国国家电气制造商协会（NEMA）模型，研究了四种不同的正电子发射断层扫描/计算机断层扫描（PET/CT）重建算法的行为。这些重建算法分别为有序子集期望最大化（OSEM）、OSEM+（点扩散函数）PSF、OSEM+飞行时间（TOF）和OSEM+ TOF + PSF，并以恢复系数为量化方法，重点关注球体大小和sbr。结果表明，在不同的球背景比（sbr）下，TOF对Gibbs伪影和部分体积效应（PVE）有显著影响。基于tof的算法提高了量化精度，减轻了Gibbs伪影的影响，特别是在较高sbr时。与PSF算法相比，基于TOF的算法有效地减轻了PVE对小尺寸球体的影响，并且减少了对sbr的依赖。在标准化吸收值（SUV）量化方面，在较低sbr条件下使用基于tof的算法SUVmean效果较好，而在较高sbr条件下使用SUVmax效果较好。TOF和PSF的结合在量化和检测各种sbr中的小尺寸球体方面产生了很好的结果，最终产生了更可靠和精确的诊断信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.