Fast Esterification Method Mediated by Coupling Reagent NDTP

Abstract

Herein, we report a rapid and mild esterification method using 5-nitro-4,6-dithiocyanatopyrimidine (NDTP) as a coupling reagent, which is effective in alcoholic and nonalcoholic solvents. The esterification process mediated by NDTP allows for the good yield synthesis of esters within just 1 min. A wide range of alcohols and carboxylic acids were effectively esterified under these optimized conditions. The method’s rapid execution, high efficiency, and adaptability across diverse substrates make it advantageous for ester synthesis.