The Effect of Electroconvulsive and Magnetic Seizure Therapy (MST) on Cortical Thickness in Schizophrenia

IF 5 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-03-03 DOI:10.1111/cns.70309

Jin Li, Junjie Wang, Yong Yang, Ju Gao, Xiaobin Zhang

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Abstract

Background

Identifying ways to conduct brain stimulation that match the clinical efficacy of electroconvulsive therapy (ECT) without the side effects of ECT is an important goal in schizophrenia (SCS). Magnetic seizure therapy (MST) is a potential alternative, which has shown considerable efficacy but with mild cognitive impairment.

Objective

This study compared the clinical efficacy and cognitive side effects of ECT and MST. In addition, we also investigated the possible contribution of cortical thickness changes to treatment response.

Methods

Thirty-four confirmed schizophrenia patients were randomly treated with ECT (n = 16) or MST (n = 18) for 4 weeks. Mental symptoms were measured through PANSS, cognition was measured through the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and changes in cortical thickness before and after treatment were compared using FreeSurfer.

Results

Both treatments reduced the PANSS score and had comparable efficacy, while MST was superior in preserving the RBANS language score.

Conclusion

In this study, neither the MST group nor the ECT group showed significant changes in cortical thickness after treatment. MST, like ECT, effectively alleviates symptoms of schizophrenia but retains cognitive function slightly better.

Trial Registration

ClinicalTrials.gov identifier: NCT02746965

Abstract Image

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电惊厥和磁发作治疗（MST）对精神分裂症皮质厚度的影响

寻找与电痉挛治疗（ECT）临床疗效相匹配且无副作用的脑刺激方法是精神分裂症（SCS）治疗的重要目标。磁发作疗法（MST）是一种潜在的替代疗法，它已经显示出相当大的疗效，但会造成轻微的认知障碍。目的比较电痉挛疗法与MST的临床疗效及认知不良反应。此外，我们还研究了皮质厚度变化对治疗反应的可能贡献。方法34例确诊精神分裂症患者随机采用电痉挛治疗（16例）或MST治疗（18例），疗程4周。通过PANSS测量精神症状，通过rban神经心理状态评估重复测试（Repeatable Battery for Assessment of Neuropsychological Status, rban）测量认知，使用FreeSurfer比较治疗前后皮质厚度变化。结果两种治疗均降低了PANSS评分，疗效相当，而MST在保留RBANS语言评分方面更优。结论在本研究中，MST组和ECT组治疗后皮质厚度均无明显变化。MST和ECT一样，能有效缓解精神分裂症的症状，但能更好地保留认知功能。试验注册ClinicalTrials.gov识别码：NCT02746965

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.